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PGR recombinant protein :: Progesterone Receptor, unactive Human, aa1-160 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS608426 PGR recombinant protein
Unit / Price
0.025 mg  /  $400 +1 FREE 8GB USB
0.1 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Progesterone Receptor, unactive Human, aa1-160 (PGR), Recombinant Protein

 Also Known As   

Progesterone Receptor, unactive, Recombinant Human, aa1-160 (Prostaglandin E synthase 3, EC 5.3.99.3, Cytosolic prostaglandin E2 synthase, cPGES, Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23)

 Product Synonym Names    Anti -Progesterone Receptor, unactive, Recombinant Human, aa1-160 (Prostaglandin E synthase 3, EC 5.3.99.3, Cytosolic prostaglandin E2 synthase, cPGES, Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23)
 Product Gene Name   

PGR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (100900355..101000544, complement). Location: 11q22-q23
 OMIM    607311
 3D Structure    ModBase 3D Structure for P06401
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10F762
 Host    Mouse
 Species Reactivity    Chicken, Guinea Pig, Human, Mouse, Rabbit
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 Specificity    Recognizes human p23. Species Crossreactivity: rabbit, chicken, guinea pig. s. cerevisiae (lower).
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide and 50% glycerol.
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 Immunogen    Recombinant Human full length p23 protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of PGR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PGR recombinant protein

   p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25kD) with a simple structure (2, 3). p23 does not have any structural
 Product Categories/Family for PGR recombinant protein    Antibodies; Abs to Prostaglandins
 Applications Tested/Suitable for PGR recombinant protein   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for PGR recombinant protein    Suitable for use in ELISA, Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:2000
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NCBI/Uniprot data below describe general gene information for PGR. It may not necessarily be applicable to this product.
 NCBI GI #    189935
 NCBI GeneID    5241
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 UniProt Primary Accession #    P06401 [Other Products]
 UniProt Secondary Accession #    Q9UPF7; A7X8B0 [Other Products]
 UniProt Related Accession #    P06401; Q6TZ07; Q6TZ08; Q8NG42; Q8NG43; Q8NG44; Q8NG45; Q8TDS3 [Other Products]
 Molecular Weight    98,981 Da [Similar Products]
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 NCBI Official Full Name    progesterone receptor
 NCBI Official Synonym Full Names    progesterone receptor
 NCBI Official Symbol    PGR [Similar Products]
 NCBI Official Synonym Symbols   
PR; NR3C3
[Similar Products]
 NCBI Protein Information    progesterone receptor; OTTHUMP00000236114; OTTHUMP00000236115; OTTHUMP00000236117; OTTHUMP00000236119; nuclear receptor subfamily 3 group C member 3
 UniProt Protein Name    Progesterone receptor
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group C member 3
 Protein Family    Protein
 UniProt Gene Name    PGR [Similar Products]
 UniProt Synonym Gene Names    NR3C3 [Similar Products]
 UniProt Entry Name    PRGR_HUMAN
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 NCBI Summary for PGR    This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq]
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 UniProt Comments for PGR    PR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; mitochondrial outer membrane

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; enzyme binding; DNA binding; zinc ion binding; steroid hormone receptor activity; steroid binding; receptor binding

Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; ovulation from ovarian follicle; signal transduction; regulation of epithelial cell proliferation

Disease: Progesterone Resistance
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 Research Articles on PGR    1. FGFR-2, STAT5, and progesterone receptors have roles in breast cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PGR recombinant proteinPathways associated with PGR recombinant protein
 Reference Product  PubMed Publications
 ESR1 recombinant protein  >57 publications with PGR and ESR1
 SRC recombinant protein  >6 publications with PGR and SRC
 KLF9 recombinant protein  >4 publications with PGR and KLF9
 SP1 recombinant protein  >4 publications with PGR and SP1
 RELA recombinant protein  >2 publications with PGR and RELA
 NCOA3 recombinant protein  >2 publications with PGR and NCOA3
 NCOA1 recombinant protein  >2 publications with PGR and NCOA1
 Products by Pathway  Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Progesterone-mediated Oocyte Maturation Pathway antibodies  Progesterone-mediated Oocyte Maturation Pathway Diagram
 Progesterone-mediated Oocyte Maturation Pathway antibodies  Progesterone-mediated Oocyte Maturation Pathway Diagram
Diseases associated with PGR recombinant proteinOrgans/Tissues associated with PGR recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1435 publications with PGR and Neoplasms
 Breast Neoplasms Antibodies  >1181 publications with PGR and Breast Neoplasms
 Carcinoma Antibodies  >554 publications with PGR and Carcinoma
 Adenocarcinoma Antibodies  >281 publications with PGR and Adenocarcinoma
 Neoplasms, Hormone-Dependent Antibodies  >153 publications with PGR and Neoplasms, Hormone-Dependent
 Female Urogenital Diseases Antibodies  >126 publications with PGR and Female Urogenital Diseases
 Neoplasms, Experimental Antibodies  >118 publications with PGR and Neoplasms, Experimental
 Neoplasm Recurrence, Local Antibodies  >114 publications with PGR and Neoplasm Recurrence, Local
 Genital Neoplasms, Female Antibodies  >100 publications with PGR and Genital Neoplasms, Female
 Uterine Neoplasms Antibodies  >82 publications with PGR and Uterine Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >121 publications with PGR and Uterus
 Vascular Antibodies  >70 publications with PGR and Vascular
 Ovary Antibodies  >57 publications with PGR and Ovary
 Muscle Antibodies  >50 publications with PGR and Muscle
 Mammary Gland Antibodies  >49 publications with PGR and Mammary Gland
 Brain Antibodies  >46 publications with PGR and Brain
 Lung Antibodies  >36 publications with PGR and Lung
 Prostate Antibodies  >22 publications with PGR and Prostate
 Stomach Antibodies  >22 publications with PGR and Stomach
 Cervix Antibodies  >16 publications with PGR and Cervix
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