NP_000917.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,747 Da
NCBI Official Full Name
progesterone receptor isoform B
NCBI Official Synonym Full Names
progesterone receptor
NCBI Official Synonym Symbols
NCBI Protein Information
progesterone receptor; nuclear receptor subfamily 3 group C member 3
UniProt Protein Name
Progesterone receptor
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group C member 3
UniProt Synonym Gene Names
UniProt Entry Name
PRGR_HUMAN
NCBI Summary for PGR
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
UniProt Comments for PGR
PR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 11q22-q23
Cellular Component: nucleoplasm; mitochondrial outer membrane
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; enzyme binding; DNA binding; zinc ion binding; steroid hormone receptor activity; steroid binding; receptor binding
Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; ovulation from ovarian follicle; signal transduction; regulation of epithelial cell proliferation
Disease: Progesterone Resistance
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Products associated with PGR recombinant protein
Pathways associated with PGR recombinant protein
Diseases associated with PGR recombinant protein
Organs/Tissues associated with PGR recombinant protein
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