Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow ALG2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • C3AR1 Antibody
 • VEGFR3 Recombinant Protein
 • microtubule-associated protein 4 (MAP4) Antibody
 • Interleukin 1 Beta (IL1b) ELISA Kit
 • Homocysteic acid, Hcy ELISA Kit
 • Atrial Natriuretic Peptide, pro-, aa40-55 (NPPA) Antibody
 • Artemin (ARTN) Recombinant Protein
 • S100A10 Antibody
 • HUMAN IMMUNODEFICIENCY VIRUS 1 gp120 (env) Antibody
 • Calcium Sensing Receptor (CASR) Antibody
 • Urokinase-Type Plasminogen Activator Receptor (U-PAR) ELISA Kit
 • Follicle Stimulating Hormone (FSH ) Protein
 • Amyloid beta A4 protein (APP) Recombinant Protein
 • IRS1 Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

ALG2 recombinant protein :: Programmed cell death protein 6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717139
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Programmed cell death protein 6 (ALG2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Programmed cell death protein 6

 Product Synonym Names    Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2
 Product Gene Name   

ALG2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    1-191aa; Full Length
 Sequence    MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V
 OMIM    601057
 3D Structure    ModBase 3D Structure for O75340
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ALG2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for ALG2 recombinant protein

   Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Ses to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca2+ affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. 5 Publications
 Product Categories/Family for ALG2 recombinant protein    Apoptosis
Section Bar
 SDS-PAGE of ALG2 recombinant protein    ALG2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ALG2. It may not necessarily be applicable to this product.
 NCBI GI #    389565483
 NCBI GeneID    10016
 NCBI Accession #    NP_001254485.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001267556.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O75340 [Other Products]
 UniProt Secondary Accession #    Q2YDC2; Q5TZS0; B2RD16; E7ESR3 [Other Products]
 UniProt Related Accession #    O75340 [Other Products]
 Molecular Weight    49.3kD
Table BarTOPTable Bar
 NCBI Official Full Name    programmed cell death protein 6 isoform 2
 NCBI Official Synonym Full Names    programmed cell death 6
 NCBI Official Symbol    PDCD6 [Similar Products]
 NCBI Official Synonym Symbols   
ALG2; ALG-2; PEF1B
[Similar Products]
 NCBI Protein Information    programmed cell death protein 6
 UniProt Protein Name    Programmed cell death protein 6
 UniProt Synonym Protein Names   
Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2
 Protein Family    Programmed cell death protein
 UniProt Gene Name    PDCD6 [Similar Products]
 UniProt Synonym Gene Names    ALG2 [Similar Products]
 UniProt Entry Name    PDCD6_HUMAN
Section Bar
 NCBI Summary for ALG2    This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
Section Bar
 UniProt Comments for ALG2    PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; nuclear membrane; nucleus

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; calcium-dependent protein binding; identical protein binding; molecular adaptor activity; protein anchor; protein binding; protein dimerization activity; protein homodimerization activity

Biological Process: angiogenesis; caspase activation; intracellular protein transport; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; proteolysis; response to calcium ion
Table BarTOPTable Bar
 

Product References and Citations for ALG2 recombinant protein

   Ganjei J.K., D'Adamio L.Urcelay E., Ibarreta D., Parrilla R., Ayuso M.S. Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004)
Section Bar
 Research Articles on ALG2    1. Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with ALG2 recombinant proteinDiseases associated with ALG2 recombinant protein
 Reference Product  PubMed Publications
 PDCD6IP recombinant protein  >21 publications with ALG2 and PDCD6IP
 SEC31A recombinant protein  >12 publications with ALG2 and SEC31A
 TSG101 recombinant protein  >9 publications with ALG2 and TSG101
 PEF1 recombinant protein  >3 publications with ALG2 and PEF1
 MCOLN1 recombinant protein  >1 publications with ALG2 and MCOLN1
 SEC31B recombinant protein  >1 publications with ALG2 and SEC31B
 DAPK1 recombinant protein  >1 publications with ALG2 and DAPK1
 MAP3K5 recombinant protein  >1 publications with ALG2 and MAP3K5
 ANXA11 recombinant protein  >1 publications with ALG2 and ANXA11
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with ALG2 and Lung Neoplasms
 Brain Diseases Antibodies  >3 publications with ALG2 and Brain Diseases
 Ovarian Neoplasms Antibodies  >3 publications with ALG2 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >3 publications with ALG2 and Ovarian Diseases
 Uterine Cervical Neoplasms Antibodies  >2 publications with ALG2 and Uterine Cervical Neoplasms
 Necrosis Antibodies  >2 publications with ALG2 and Necrosis
 Urinary Bladder Neoplasms Antibodies  >1 publications with ALG2 and Urinary Bladder Neoplasms
 Liver Neoplasms Antibodies  >1 publications with ALG2 and Liver Neoplasms
Organs/Tissues associated with ALG2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with ALG2 and Blood
 Lung Antibodies  >6 publications with ALG2 and Lung
 Kidney Antibodies  >4 publications with ALG2 and Kidney
 Vascular Antibodies  >4 publications with ALG2 and Vascular
 Brain Antibodies  >4 publications with ALG2 and Brain
 Muscle Antibodies  >3 publications with ALG2 and Muscle
 Ovary Antibodies  >3 publications with ALG2 and Ovary
 Stomach Antibodies  >2 publications with ALG2 and Stomach
 Eye Antibodies  >2 publications with ALG2 and Eye
 Liver Antibodies  >2 publications with ALG2 and Liver
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions