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| Product Name
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Progranulin (PGRN), Recombinant Protein ★Popular Item★
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| Also Known As
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Recombinant Human Progranulin
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| Product Synonym Names
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PGRN Human; Progranulin Human Recombinant; GRN; PGRN; granulin; Acrogranin; propithelin; PC cell derived growth Factor; GEP; GP88; PEPI; PCDGF
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| OMIM
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138945
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| 3D Structure
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ModBase 3D Structure for P28799
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| Host
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HEK 293 cells
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| Purity/Purification
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Greater than 95.0% as determined by SDS-PAGE.
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| Form/Format
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The protein solution contains 1xPBS.
Sterile Filtered clear solution.
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| Concentration
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100ug/200ul (lot specific)
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| Biological Activity
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Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells.
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| Preparation and Storage
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Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
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| Other Notes
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Small volumes of PGRN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Description: Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 70kDa. The Progranulin is purified by standard chromatographic techniques.
Introduction: A 88-kDa progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
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| Product Categories/Family for PGRN recombinant protein
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CYTOKINES AND GROWTH FACTORS; Growth Factors
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| NCBI/Uniprot data below describe general gene information for PGRN. It may not necessarily be applicable to this product. |
| NCBI GI #
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4504151
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| NCBI GeneID
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2896
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| NCBI Accession #
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NP_002078.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_002087.3
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[Other Products]
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| UniProt Primary Accession #
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P28799
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[Other Products]
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| UniProt Secondary Accession #
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P23781; P23782; P23783; P23784; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0; D3DX55
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[Other Products]
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| UniProt Related Accession #
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P28799
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[Other Products]
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| Molecular Weight
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44,132 Da
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| NCBI Official Full Name
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granulins
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| NCBI Official Synonym Full Names
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granulin
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| NCBI Official Symbol
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GRN
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[Similar Products]
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| NCBI Official Synonym Symbols
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GEP; GP88; PEPI; PGRN; CLN11; PCDGF
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[Similar Products]
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| NCBI Protein Information
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granulins; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin
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| UniProt Protein Name
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Granulins
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| UniProt Synonym Protein Names
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Proepithelin; PEPI
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| UniProt Gene Name
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GRN
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[Similar Products]
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| UniProt Synonym Gene Names
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PEPI; GP88; Glycoprotein 88
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[Similar Products]
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| UniProt Entry Name
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GRN_HUMAN
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| NCBI Summary for PGRN
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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
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| UniProt Comments for PGRN
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GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion
Molecular Function: protein binding; growth factor activity; cytokine activity
Biological Process: blastocyst hatching; signal transduction; embryo implantation; positive regulation of epithelial cell proliferation
Disease: Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Ceroid Lipofuscinosis, Neuronal, 11
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| Research Articles on PGRN
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1. This study confirmed that specific GRN single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with PGRN recombinant protein | Pathways associated with PGRN recombinant protein |
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| Diseases associated with PGRN recombinant protein | Organs/Tissues associated with PGRN recombinant protein |
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Recombinant Protein 
