Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow PGRN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • STIP1 cDNA Clone
 • SERPINA1 - Alpha 1 Antitrypsin Antibody
 • Tissue Plasminogen Activator (tPA) (PLAT) Antibody
 • Insulin-Like Growth Factor I Receptor (IGF1R) Antibody
 • ADAM metallopeptidase domain 17 (ADAM17) ELISA Kit
 • IL-12 ELISA Kit
 • Cadherin 5 (CDH5) ELISA Kit
 • ZNF38 Antibody
 • Goat anti Rabbit IgG (H + L) (HRP) Secondary Antibody
 • WDFY4 Antibody
 • Dihydrotestosterone (DHT) ELISA Kit
 • Follicle-stimulating hormone (FSH) ELISA Kit
 • Dynactin subunit 3 (DCTN3) Recombinant Protein
 • CD31 (PECAM1) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PGRN recombinant protein :: Progranulin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143184 PGRN recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Progranulin (PGRN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Progranulin

 Product Synonym Names    PGRN Human; Progranulin Human Recombinant; GRN; PGRN; granulin; Acrogranin; propithelin; PC cell derived growth Factor; GEP; GP88; PEPI; PCDGF
 Product Gene Name   

PGRN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    138945
 3D Structure    ModBase 3D Structure for P28799
Section Bar
 Host    HEK 293 cells
Section Bar
 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The protein solution contains 1xPBS.
Sterile Filtered clear solution.
 Concentration    100ug/200ul (lot specific)
Section Bar
 Biological Activity    Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells.
Section Bar
 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PGRN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for PGRN recombinant protein

   Description: Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 70kDa. The Progranulin is purified by standard chromatographic techniques.

Introduction: A 88-kDa progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
 Product Categories/Family for PGRN recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors
NCBI/Uniprot data below describe general gene information for PGRN. It may not necessarily be applicable to this product.
 NCBI GI #    4504151
 NCBI GeneID    2896
 NCBI Accession #    NP_002078.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002087.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P28799 [Other Products]
 UniProt Secondary Accession #    P23781; P23782; P23783; P23784; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0; D3DX55 [Other Products]
 UniProt Related Accession #    P28799 [Other Products]
 Molecular Weight    44,132 Da
Table BarTOPTable Bar
 NCBI Official Full Name    granulins
 NCBI Official Synonym Full Names    granulin
 NCBI Official Symbol    GRN [Similar Products]
 NCBI Official Synonym Symbols   
GEP; GP88; PEPI; PGRN; CLN11; PCDGF
[Similar Products]
 NCBI Protein Information    granulins; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin
 UniProt Protein Name    Granulins
 UniProt Synonym Protein Names   
Proepithelin; PEPI
 UniProt Gene Name    GRN [Similar Products]
 UniProt Synonym Gene Names    PEPI; GP88; Glycoprotein 88 [Similar Products]
 UniProt Entry Name    GRN_HUMAN
Section Bar
 NCBI Summary for PGRN    Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for PGRN    GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion

Molecular Function: protein binding; growth factor activity; cytokine activity

Biological Process: blastocyst hatching; signal transduction; embryo implantation; positive regulation of epithelial cell proliferation

Disease: Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Ceroid Lipofuscinosis, Neuronal, 11
Table BarTOPTable Bar
 Research Articles on PGRN    1. This study confirmed that specific GRN single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with PGRN recombinant proteinPathways associated with PGRN recombinant protein
 Reference Product  PubMed Publications
 CHMP2B recombinant protein  >29 publications with PGRN and CHMP2B
 TARDBP recombinant protein  >19 publications with PGRN and TARDBP
 SLPI recombinant protein  >8 publications with PGRN and SLPI
 VEGFA recombinant protein  >6 publications with PGRN and VEGFA
 CCND1 recombinant protein  >3 publications with PGRN and CCND1
 MMP12 recombinant protein  >1 publications with PGRN and MMP12
 CCNT1 recombinant protein  >1 publications with PGRN and CCNT1
 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with PGRN recombinant proteinOrgans/Tissues associated with PGRN recombinant protein
 Disease Name  Pubmed Publications
 Dementia Antibodies  >388 publications with PGRN and Dementia
 Nervous System Diseases Antibodies  >380 publications with PGRN and Nervous System Diseases
 Brain Diseases Antibodies  >358 publications with PGRN and Brain Diseases
 Frontotemporal Lobar Degeneration Antibodies  >318 publications with PGRN and Frontotemporal Lobar Degeneration
 Frontotemporal Dementia Antibodies  >284 publications with PGRN and Frontotemporal Dementia
 Inflammation Antibodies  >72 publications with PGRN and Inflammation
 Necrosis Antibodies  >38 publications with PGRN and Necrosis
 Nerve Degeneration Antibodies  >38 publications with PGRN and Nerve Degeneration
 Cognition Disorders Antibodies  >24 publications with PGRN and Cognition Disorders
 Memory Disorders Antibodies  >23 publications with PGRN and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >275 publications with PGRN and Brain
 Blood Antibodies  >163 publications with PGRN and Blood
 Nerve Antibodies  >66 publications with PGRN and Nerve
 Embryonic Tissue Antibodies  >38 publications with PGRN and Embryonic Tissue
 Vascular Antibodies  >35 publications with PGRN and Vascular
 Bone Antibodies  >29 publications with PGRN and Bone
 Muscle Antibodies  >26 publications with PGRN and Muscle
 Liver Antibodies  >26 publications with PGRN and Liver
 Heart Antibodies  >24 publications with PGRN and Heart
 Lung Antibodies  >18 publications with PGRN and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions