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PA2G4 recombinant protein :: Proliferation-associated protein 2G4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143577 PA2G4 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proliferation-associated protein 2G4 (PA2G4), Recombinant Protein

 Also Known As   

Recombinant Human Proliferation-associated protein 2G4

 Product Synonym Names    PA2G4 Human; Proliferation-associated protein 2G4 Human Recombinant; Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1; PA2G4; EBP1; p38-2G4
 Product Gene Name   

PA2G4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGDLEHHHH HH
 OMIM    602145
 3D Structure    ModBase 3D Structure for Q9UQ80
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The PA2G4 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PA2G4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PA2G4 recombinant protein

   Description: PA2G4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 402 amino acids (1-394 a.a.) and having a molecular mass of 44.8kDa. PA2G4 is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques.

Introduction: PA2G4 belongs to the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. PA2G4 is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. Also, PA2G4 interacts with ErbB-3 and may function as a modulator of the ErbB-3 mediated signal transduction pathway by regulating the effects of Neuregulin-1. Furthermore, PA2G4 is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. PA2G4 is implicated in growth inhibition and the induction of differentiation of human cancer cells. In addition, PA2G4 mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). PA2G4 associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA.
 Product Categories/Family for PA2G4 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for PA2G4. It may not necessarily be applicable to this product.
 NCBI GI #    124494254
 NCBI GeneID    5036
 NCBI Accession #    NP_006182.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006191.2 [Other Products]
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 UniProt Primary Accession #    Q9UQ80 [Other Products]
 UniProt Secondary Accession #    O43846; Q9UM59 [Other Products]
 UniProt Related Accession #    Q9UQ80 [Other Products]
 Molecular Weight    38,059 Da
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 NCBI Official Full Name    proliferation-associated protein 2G4
 NCBI Official Synonym Full Names    proliferation-associated 2G4, 38kDa
 NCBI Official Symbol    PA2G4 [Similar Products]
 NCBI Official Synonym Symbols   
EBP1; HG4-1; p38-2G4
[Similar Products]
 NCBI Protein Information    proliferation-associated protein 2G4; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog; erbB3-binding protein 1; proliferation-associated 2G4, 38kD
 UniProt Protein Name    Proliferation-associated protein 2G4
 UniProt Synonym Protein Names   
Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1
 Protein Family    Proliferation-associated protein
 UniProt Gene Name    PA2G4 [Similar Products]
 UniProt Synonym Gene Names    EBP1; hG4-1 [Similar Products]
 UniProt Entry Name    PA2G4_HUMAN
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 NCBI Summary for PA2G4    This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PA2G4    Ebp1: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Belongs to the peptidase M24 family.

Protein type: Nucleolus; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; ribonucleoprotein complex; nucleus

Molecular Function: protein binding; DNA binding; ubiquitin protein ligase binding; transcription factor activity

Biological Process: regulation of translation; cell proliferation; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; positive regulation of cell differentiation; cell cycle arrest; rRNA processing; negative regulation of apoptosis
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 Research Articles on PA2G4    1. Ebp1 p42 isoform regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PA2G4 recombinant proteinPathways associated with PA2G4 recombinant protein
 Reference Product  PubMed Publications
 ERBB3 recombinant protein  >34 publications with PA2G4 and ERBB3
 AKT1 recombinant protein  >1 publications with PA2G4 and AKT1
 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
Diseases associated with PA2G4 recombinant proteinOrgans/Tissues associated with PA2G4 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >11 publications with PA2G4 and Breast Neoplasms
 Disease Progression Antibodies  >8 publications with PA2G4 and Disease Progression
 Disease Models, Animal Antibodies  >4 publications with PA2G4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with PA2G4 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >3 publications with PA2G4 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >2 publications with PA2G4 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >2 publications with PA2G4 and Inflammation
 Hypertrophy Antibodies  >1 publications with PA2G4 and Hypertrophy
 Heart Diseases Antibodies  >1 publications with PA2G4 and Heart Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with PA2G4 and Urinary Bladder Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >12 publications with PA2G4 and Prostate
 Blood Antibodies  >6 publications with PA2G4 and Blood
 Salivary Gland Antibodies  >4 publications with PA2G4 and Salivary Gland
 Mouth Antibodies  >4 publications with PA2G4 and Mouth
 Muscle Antibodies  >4 publications with PA2G4 and Muscle
 Brain Antibodies  >4 publications with PA2G4 and Brain
 Embryonic Tissue Antibodies  >2 publications with PA2G4 and Embryonic Tissue
 Vascular Antibodies  >2 publications with PA2G4 and Vascular
 Heart Antibodies  >2 publications with PA2G4 and Heart
 Mammary Gland Antibodies  >2 publications with PA2G4 and Mammary Gland
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