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Prom1 recombinant protein :: Prominin-1 (Prom1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1143448
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prominin-1 (Prom1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Prominin-1 (Prom1)

 Product Synonym Names    Recombinant Prominin-1 (Prom1); Prominin-1; Antigen AC133 homolog Prominin-like protein 1 CD_antigen= CD133
 Product Gene Name   

Prom1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Prom1; Prom, Proml1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1143448 COA    COA PDF
 Sequence Positions    509-794aa; Extracellular Domain
 Sequence    GANVEKLLCE PYENKKLLQV LDTPYLLKEQ WQFYLSGMLF NNPDINMTFE QVYRDCKRGR GIYAAFQLEN VVNVSDHFNI DQISENINTE LENLNVNIDS IELLDNTGRK SLEDFAHSGI DTIDYSTYLK ETEKSPTEVN LLTFASTLEA KANQLPEGKP KQAFLLDVQN IRAIHQHLLP PVQQSLNTLR QSVWTLQQTS NKLPEKVKKI LASLDSVQHF LTNNVSLIVI GETKKFGKTI LGYFEHYLHW VFYAITEKMT SCKPMATAMD SAVNGILCGY VADPLN
 Chromosome Location    Chromosome: 5; NC_000071.6 (43993622..44101736, complement). Location: 5 B3; 5
 3D Structure    ModBase 3D Structure for O54990
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Prom1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Prom1 recombinant protein

   May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
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 SDS-PAGE of Prom1 recombinant protein    Prom1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Prom1. It may not necessarily be applicable to this product.
 NCBI GI #    254675304
 NCBI GeneID    19126
 NCBI Accession #    NP_001157050.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163578.1 [Other Products]
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 UniProt Primary Accession #    O54990 [Other Products]
 UniProt Secondary Accession #    O35408; Q80XB2; Q80XB3; Q80XB6; Q8BH12 [Other Products]
 UniProt Related Accession #    O54990 [Other Products]
 Molecular Weight    97,113 Da [Similar Products]
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 NCBI Official Full Name    prominin-1 isoform s3
 NCBI Official Synonym Full Names    prominin 1
 NCBI Official Symbol    Prom1 [Similar Products]
 NCBI Official Synonym Symbols   
Prom; AC133; CD133; Prom-1; Proml1; 4932416E19Rik
[Similar Products]
 NCBI Protein Information    prominin-1; prominin-like 1; antigen AC133 homolog; prominin-like protein 1
 UniProt Protein Name    Prominin-1
 UniProt Synonym Protein Names   
Antigen AC133 homolog; Prominin-like protein 1
 Protein Family    Prominin
 UniProt Gene Name    Prom1 [Similar Products]
 UniProt Synonym Gene Names    Prom; Proml1 [Similar Products]
 UniProt Entry Name    PROM1_MOUSE
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 UniProt Comments for Prom1    CD133: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Interacts with CDHR1 and with actin filaments. Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells. Expressed in adult retina by rod and cone photoreceptor cells. Belongs to the prominin family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: extracellular space; microvillus; cell surface; endoplasmic reticulum; integral to plasma membrane; ER-Golgi intermediate compartment; integral to membrane; cilium; stereocilium; cell projection; photoreceptor outer segment; membrane; apical plasma membrane; plasma membrane; brush border; vesicle

Molecular Function: actinin binding; cadherin binding

Biological Process: photoreceptor cell maintenance; retina morphogenesis in camera-type eye
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 Research Articles on Prom1    1. Evidence for self-renewal capacity was obtained by serial transplantation of long-term epidermal repopulating units derived from CD133(+) and CD133(+)DeltaPsim(hi) keratinocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Prom1 recombinant proteinDiseases associated with Prom1 recombinant protein
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with Prom1 and Neoplasms
 Gastrointestinal Diseases Antibodies  >8 publications with Prom1 and Gastrointestinal Diseases
 Retinitis Pigmentosa Antibodies  >7 publications with Prom1 and Retinitis Pigmentosa
 Colorectal Neoplasms Antibodies  >6 publications with Prom1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >3 publications with Prom1 and Adenocarcinoma
 Brain Diseases Antibodies  >3 publications with Prom1 and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with Prom1 and Nervous System Diseases
 Glioblastoma Antibodies  >3 publications with Prom1 and Glioblastoma
 Liver Neoplasms Antibodies  >2 publications with Prom1 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with Prom1 and Cell Transformation, Neoplastic
Organs/Tissues associated with Prom1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >11 publications with Prom1 and Other
 Eye Antibodies  >9 publications with Prom1 and Eye
 Liver Antibodies  >7 publications with Prom1 and Liver
 Brain Antibodies  >7 publications with Prom1 and Brain
 Blood Antibodies  >4 publications with Prom1 and Blood
 Intestine Antibodies  >3 publications with Prom1 and Intestine
 Mammary Gland Antibodies  >2 publications with Prom1 and Mammary Gland
 Testis Antibodies  >2 publications with Prom1 and Testis
 Embryonic Tissue Antibodies  >2 publications with Prom1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with Prom1 and Kidney
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