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PROM1 recombinant protein :: Prominin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1151261
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prominin-1 (PROM1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Prominin-1

 Product Synonym Names    Antigen AC133; Prominin-like protein 1; CD133
 Product Gene Name   

PROM1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1151261 COA    COA PDF
 Sequence Positions    508-792. Partial, provide a fragment of the complete extracellular domain.
 Sequence    GANVEKLICE PYTSKELFRV LDTPYLLNED WEYYLSGKLF NKSKMKLTFE QVYSDCKKNR GTYGTLHLQN SFNISEHLNI NEHTGSISSE LESLKVNLNI FLLGAAGRKN LQDFAACGID RMNYDSYLAQ TGKSPAGVNL LSFAYDLEAK ANSLPPGNLR NSLKRDAQTI KTIHQQRVLP IEQSLSTLYQ SVKILQRTGN GLLERVTRIL ASLDFAQNFI TNNTSSVIIE ETKKYGRTII GYFEHYLQWI EFSISEKVAS CKPVATALDT AVDVFLCSYI IDPLN
 OMIM    603786
 3D Structure    ModBase 3D Structure for O43490
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PROM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PROM1 recombinant protein

   May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
 Product Categories/Family for PROM1 recombinant protein    Epigenetics and Nuclear Signaling
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 SDS-Page of PROM1 recombinant protein    PROM1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PROM1. It may not necessarily be applicable to this product.
 NCBI GI #    224994189
 NCBI GeneID    8842
 NCBI Accession #    NP_001139319.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145847.1 [Other Products]
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 UniProt Primary Accession #    O43490 [Other Products]
 UniProt Secondary Accession #    Q6SV49; Q6SV50; Q6SV51; Q6SV52; Q6SV53; Q96EN6 [Other Products]
 UniProt Related Accession #    O43490 [Other Products]
 Molecular Weight    34.16kD
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 NCBI Official Full Name    prominin-1 isoform 2
 NCBI Official Synonym Full Names    prominin 1
 NCBI Official Symbol    PROM1 [Similar Products]
 NCBI Official Synonym Symbols   
RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061
[Similar Products]
 NCBI Protein Information    prominin-1
 UniProt Protein Name    Prominin-1
 UniProt Synonym Protein Names   
Antigen AC133; Prominin-like protein 1; CD_antigen: CD133
 Protein Family    Prominin
 UniProt Gene Name    PROM1 [Similar Products]
 UniProt Synonym Gene Names    PROML1 [Similar Products]
 UniProt Entry Name    PROM1_HUMAN
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 NCBI Summary for PROM1    This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for PROM1    CD133: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Interacts with CDHR1 and with actin filaments. Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells. Expressed in adult retina by rod and cone photoreceptor cells. Belongs to the prominin family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p15.32

Cellular Component: apical plasma membrane; brush border; cell surface; endoplasmic reticulum; ER-Golgi intermediate compartment; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; microvillus membrane; photoreceptor outer segment; plasma membrane; stereocilium; vesicle

Molecular Function: actinin binding; cadherin binding; protein binding

Biological Process: photoreceptor cell maintenance; retina morphogenesis in camera-type eye

Disease: Cone-rod Dystrophy 12; Macular Dystrophy, Retinal, 2; Retinitis Pigmentosa 41; Stargardt Disease 4
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Product References and Citations for PROM1 recombinant protein

   A novel five-transmembrane hematopoietic stem cell antigen isolation, characterization, and molecular cloning.Miraglia S., Godfrey W., Yin A.H., Atkins K., Warnke R., Holden J.T., Bray R.A., Waller E.K., Buck D.W.Blood 90:5013-5021(1997) AC133-2, a novel isoform of human AC133 stem cell antigen.Yu Y., Flint A., Dvorin E.L., Bischoff J.J. Biol. Chem. 277:20711-20716(2002) Identification and functional analysis of several isoforms of hematopoitic stem cell surface maker prominin-1 (AC133) .Lin J., Shmelkov S.V., Karajannis M.A., StClair R., Walsh K., Gordon R., Shido K., Lam G., Moussazadeh N., Shim W., Rafii S.Wang X.Y., Zhao B., Liu B., Xu Y.Y., Liu Y.Q., Cao H.Q., Sheng H., Ye J., Song L., Wei Y.J., Liu S., Liu L.S., Ding J.F., Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005)
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 Research Articles on PROM1    1. CD133 antigen was found to be a tumor marker in primary myelofibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PROM1 recombinant proteinPathways associated with PROM1 recombinant protein
 Reference Product  PubMed Publications
 SOX2 recombinant protein  >7 publications with PROM1 and SOX2
 HIF1A recombinant protein  >3 publications with PROM1 and HIF1A
 TP53 recombinant protein  >3 publications with PROM1 and TP53
 MYC recombinant protein  >2 publications with PROM1 and MYC
 CDHR1 recombinant protein  >2 publications with PROM1 and CDHR1
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with PROM1 recombinant proteinOrgans/Tissues associated with PROM1 recombinant protein
 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >14 publications with PROM1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >11 publications with PROM1 and Adenocarcinoma
 Glioblastoma Antibodies  >9 publications with PROM1 and Glioblastoma
 Disease Models, Animal Antibodies  >6 publications with PROM1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >6 publications with PROM1 and Neoplasm Metastasis
 Colonic Neoplasms Antibodies  >5 publications with PROM1 and Colonic Neoplasms
 Breast Neoplasms Antibodies  >4 publications with PROM1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with PROM1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >3 publications with PROM1 and Liver Neoplasms
 Inflammation Antibodies  >3 publications with PROM1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >19 publications with PROM1 and Eye
 Brain Antibodies  >18 publications with PROM1 and Brain
 Liver Antibodies  >12 publications with PROM1 and Liver
 Lung Antibodies  >5 publications with PROM1 and Lung
 Nerve Antibodies  >5 publications with PROM1 and Nerve
 Intestine Antibodies  >4 publications with PROM1 and Intestine
 Embryonic Tissue Antibodies  >4 publications with PROM1 and Embryonic Tissue
 Testis Antibodies  >3 publications with PROM1 and Testis
 Stomach Antibodies  >2 publications with PROM1 and Stomach
 Mammary Gland Antibodies  >1 publications with PROM1 and Mammary Gland
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