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PCSK5 recombinant protein :: Proprotein Convertase Subtilisin/Kexin Type 5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031660 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-Page
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $270 +1 FREE 8GB USB
0.1 mg  /  $420 +1 FREE 8GB USB
0.2 mg  /  $515 +1 FREE 8GB USB
0.5 mg  /  $995 +1 FREE 8GB USB
1 mg  /  $1,480 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5)

 Product Gene Name   

PCSK5 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Proprotein Convertase Subtilisin/Kexin Type 5 (MBS2026024)
Antigen: Proprotein Convertase Subtilisin/Kexin Type 5 (MBS2031660)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2031660 Technical Datasheet    Technical Datasheet PDF
 Sequence    DYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE AMVM
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 Host    E.coli
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 Purity/Purification    > 97%
 Form/Format    100mMNaHCO3, 500mMNaCl, pH8.3, containing 0.01% SKL, 5% Trehalose.
 Concentration    Original Concentration: 200ug/mL (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Prokaryotic expression
 Residues    Asp115~Met454
 Tags    N-terminal His Tag
 Subcellular Location    Secreted
 Traits    Freeze-dried powder
 Predicted isoelectric point    5.6
 Predicted Molecular Mass    40.8kDa
 Accurate Molecular Mass    41kDa as determined by SDS-PAGE reducing conditions.
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of PCSK5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PCSK5 recombinant protein   

Positive Control; Immunogen; SDS-PAGE; WB.
(May be suitable for use in other assays to be determined by the end user.)

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 SDS-Page of PCSK5 recombinant protein    PCSK5 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PCSK5. It may not necessarily be applicable to this product.
 NCBI GI #    299523019
 NCBI GeneID    18552
 NCBI Accession #    NP_001177412.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190483.2 [Other Products]
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 UniProt Secondary Accession #    Q62040; E9QPB7 [Other Products]
 UniProt Related Accession #    Q04592 [Other Products]
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 NCBI Official Full Name    proprotein convertase subtilisin/kexin type 5 isoform 1 preproprotein
 NCBI Official Synonym Full Names    proprotein convertase subtilisin/kexin type 5
 NCBI Official Symbol    Pcsk5 [Similar Products]
 NCBI Official Synonym Symbols   
PC5; PC6; SPC6; b2b585Clo; b2b1549Clo
[Similar Products]
 NCBI Protein Information    proprotein convertase subtilisin/kexin type 5
 UniProt Protein Name    Proprotein convertase subtilisin/kexin type 5
 UniProt Synonym Protein Names   
Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; Subtilisin-like proprotein convertase 6; SPC6; Subtilisin/kexin-like protease PC5
 Protein Family    Proprotein convertase subtilisin/kexin
 UniProt Gene Name    Pcsk5 [Similar Products]
 UniProt Synonym Gene Names    PC5; PC6; SPC6 [Similar Products]
 UniProt Entry Name    PCSK5_MOUSE
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 NCBI Summary for PCSK5    This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
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 UniProt Comments for PCSK5    PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.21.-; Membrane protein, integral

Cellular Component: Golgi apparatus; extracellular space; membrane; extracellular region; integral to membrane; secretory granule

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity; peptide binding

Biological Process: signal peptide processing; heart development; respiratory tube development; embryonic skeletal development; cytokine biosynthetic process; peptide hormone processing; female pregnancy; viral infectious cycle; proteolysis; limb morphogenesis; peptide biosynthetic process; anterior/posterior pattern formation; protein processing; kidney development; embryonic gut development; embryo implantation
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 Research Articles on PCSK5    1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PCSK5 recombinant proteinPathways associated with PCSK5 recombinant protein
 Reference Product  PubMed Publications
 Furin recombinant protein  >10 publications with PCSK5 and Furin
 Pcsk7 recombinant protein  >8 publications with PCSK5 and Pcsk7
 Pcsk6 recombinant protein  >6 publications with PCSK5 and Pcsk6
 Pcsk1 recombinant protein  >4 publications with PCSK5 and Pcsk1
 Mbtps1 recombinant protein  >4 publications with PCSK5 and Mbtps1
 Pcsk9 recombinant protein  >4 publications with PCSK5 and Pcsk9
 Pcsk4 recombinant protein  >2 publications with PCSK5 and Pcsk4
 Pcsk2 recombinant protein  >2 publications with PCSK5 and Pcsk2
 Products by Pathway  Pathway Diagram
 NGF Processing Pathway antibodies  NGF Processing Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
Diseases associated with PCSK5 recombinant proteinOrgans/Tissues associated with PCSK5 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with PCSK5 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >2 publications with PCSK5 and Heart Defects, Congenital
 Anus, Imperforate Antibodies  >2 publications with PCSK5 and Anus, Imperforate
 Cell Transformation, Neoplastic Antibodies  >1 publications with PCSK5 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with PCSK5 and Liver Diseases
 Inflammation Antibodies  >1 publications with PCSK5 and Inflammation
 Necrosis Antibodies  >1 publications with PCSK5 and Necrosis
 Tracheoesophageal Fistula Antibodies  >1 publications with PCSK5 and Tracheoesophageal Fistula
 Lung Diseases Antibodies  >1 publications with PCSK5 and Lung Diseases
 Neoplasm Metastasis Antibodies  >1 publications with PCSK5 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >4 publications with PCSK5 and Intestine
 Ovary Antibodies  >3 publications with PCSK5 and Ovary
 Kidney Antibodies  >3 publications with PCSK5 and Kidney
 Liver Antibodies  >2 publications with PCSK5 and Liver
 Embryonic Tissue Antibodies  >2 publications with PCSK5 and Embryonic Tissue
 Lung Antibodies  >1 publications with PCSK5 and Lung
 Extraembryonic Tissue Antibodies  >1 publications with PCSK5 and Extraembryonic Tissue
 Mammary Gland Antibodies  >1 publications with PCSK5 and Mammary Gland
 Brain Antibodies  >1 publications with PCSK5 and Brain
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