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Pcsk5 recombinant protein :: Proprotein convertase subtilisin/kexin type 5 (Pcsk5) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953694 Pcsk5 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proprotein convertase subtilisin/kexin type 5 (Pcsk5), Recombinant Protein

 Also Known As   

Recombinant Rat Proprotein convertase subtilisin/kexin type 5 (Pcsk5) , partial

 Product Gene Name   

Pcsk5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P41413
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Pcsk5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Pcsk5 recombinant protein

   This protein belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.
NCBI/Uniprot data below describe general gene information for Pcsk5. It may not necessarily be applicable to this product.
 NCBI GI #    457866801
 NCBI GeneID    116548
 NCBI Accession #    NP_446275.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053823.1 [Other Products]
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 UniProt Primary Accession #    P41413 [Other Products]
 UniProt Secondary Accession #    Q62914; D3ZVZ3 [Other Products]
 UniProt Related Accession #    P41413 [Other Products]
 Molecular Weight    101,454 Da
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 NCBI Official Full Name    proprotein convertase subtilisin/kexin type 5 preproprotein
 NCBI Official Synonym Full Names    proprotein convertase subtilisin/kexin type 5
 NCBI Official Symbol    Pcsk5 [Similar Products]
 NCBI Official Synonym Symbols   
PC6; Pc5
[Similar Products]
 NCBI Protein Information    proprotein convertase subtilisin/kexin type 5
 UniProt Protein Name    Proprotein convertase subtilisin/kexin type 5
 UniProt Synonym Protein Names   
Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; Subtilisin/kexin-like protease PC5; rPC5
 Protein Family    Proprotein convertase subtilisin/kexin
 UniProt Gene Name    Pcsk5 [Similar Products]
 UniProt Synonym Gene Names    PC5; PC6; rPC5 [Similar Products]
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 NCBI Summary for Pcsk5    may play a role in peptide processing and maturation [RGD, Feb 2006]
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 UniProt Comments for Pcsk5    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
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 Research Articles on Pcsk5    1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Pcsk5 recombinant proteinPathways associated with Pcsk5 recombinant protein
 Reference Product  PubMed Publications
 Furin recombinant protein  >8 publications with Pcsk5 and Furin
 Pcsk6 recombinant protein  >6 publications with Pcsk5 and Pcsk6
 Gdf11 recombinant protein  >3 publications with Pcsk5 and Gdf11
 Products by Pathway  Pathway Diagram
 NGF Processing Pathway antibodies  NGF Processing Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
Diseases associated with Pcsk5 recombinant proteinOrgans/Tissues associated with Pcsk5 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with Pcsk5 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >2 publications with Pcsk5 and Congenital Abnormalities
 Caudal regression syndrome Antibodies  >2 publications with Pcsk5 and Caudal regression syndrome
 Vascular Diseases Antibodies  >1 publications with Pcsk5 and Vascular Diseases
 Atherosclerosis Antibodies  >1 publications with Pcsk5 and Atherosclerosis
 Inflammation Antibodies  >1 publications with Pcsk5 and Inflammation
 Necrosis Antibodies  >1 publications with Pcsk5 and Necrosis
 Liver Diseases Antibodies  >1 publications with Pcsk5 and Liver Diseases
 Anus, Imperforate Antibodies  >1 publications with Pcsk5 and Anus, Imperforate
 Kidney Diseases Antibodies  >1 publications with Pcsk5 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >2 publications with Pcsk5 and Heart
 Liver Antibodies  >2 publications with Pcsk5 and Liver
 Ovary Antibodies  >2 publications with Pcsk5 and Ovary
 Embryonic Tissue Antibodies  >2 publications with Pcsk5 and Embryonic Tissue
 Colon Antibodies  >1 publications with Pcsk5 and Colon
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