P30557.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
Prostaglandin E2 receptor EP3 subtype
NCBI Official Synonym Full Names
prostaglandin E receptor 3 (subtype EP3)
NCBI Protein Information
prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor; PGE receptor EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor EP3 subtype
UniProt Protein Name
Prostaglandin E2 receptor EP3 subtype
UniProt Synonym Protein Names
Prostanoid EP3 receptor
UniProt Synonym Gene Names
UniProt Entry Name
PE2R3_MOUSE
UniProt Comments for Ptger3
PTGER3: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Cellular Component: membrane; integral to membrane; plasma membrane; cytosol
Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; prostaglandin receptor activity; prostaglandin E receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; bicarbonate transport; positive regulation of fever; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); response to lipopolysaccharide; signal transduction; fever
Research Articles on Ptger3
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Pathways associated with Ptger3 recombinant protein
Organs/Tissues associated with Ptger3 recombinant protein
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