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PSMB5 recombinant protein :: Proteasome Subunit Beta Type 5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144287 PSMB5 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proteasome Subunit Beta Type 5 (PSMB5), Recombinant Protein

 Also Known As   

Recombinant Human Proteasome Subunit Beta Type 5

 Product Synonym Names    PSMB5 Human; Proteasome Subunit Beta Type 5 Human Recombinant; Proteasome subunit beta type-5; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit X; PSMB5; LMPX; MB1; X; MGC104214
 Product Gene Name   

PSMB5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGS MTTT LAFKFRHGVI VAADSRATAG AYIASQTVKK VIEINPYLLG TMAGGAADCS FWERLLARQC RIYELRNKER ISVAAASKLL ANMVYQYKGM GLSMGTMICG WDKRGPGLYY VDSEGNRISG ATFSVGSGSV YAYGVMDRGY SYDLEVEQAY DLARRAIYQA TYRDAYSGGA VNLYHVREDG WIRVSSDNVA DLHEKYSGST P
 OMIM    600306
 3D Structure    ModBase 3D Structure for P28074
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The PSMB5 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 5mM DTT and 0.2M NaCl.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PSMB5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PSMB5 recombinant protein

   Description: PSMB5 Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 241 amino acids (60-263 a.a.) and having a molecular mass of 26.7kDa. The PSMB5 is purified by proprietary chromatographic techniques.

Introduction: PSMB5 belongs to the proteasome B-type family that has a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is substituted by catalytic subunit 3i (proteasome beta 8 subunit). A fundamental function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB5 exhibits an ATP dependent proteolytic activity and is involved in an ATP/ubiquitin dependent non lysosomal proteolytic pathway.
 Product Categories/Family for PSMB5 recombinant protein    ENZYMES; Enzymes; Proteasome
NCBI/Uniprot data below describe general gene information for PSMB5. It may not necessarily be applicable to this product.
 NCBI GI #    195539356
 NCBI GeneID    5693
 NCBI Accession #    NP_001124197.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130725.1 [Other Products]
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 UniProt Primary Accession #    P28074 [Other Products]
 UniProt Secondary Accession #    Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9; B2R4N9; B4DUM9; D3DS43; E9PAV2 [Other Products]
 UniProt Related Accession #    P28074 [Other Products]
 Molecular Weight    17,782 Da
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 NCBI Official Full Name    proteasome subunit beta type-5 isoform 2
 NCBI Official Synonym Full Names    proteasome (prosome, macropain) subunit, beta type, 5
 NCBI Official Symbol    PSMB5 [Similar Products]
 NCBI Official Synonym Symbols   
X; MB1; LMPX
[Similar Products]
 NCBI Protein Information    proteasome subunit beta type-5; PSX large multifunctional protease X; macropain epsilon chain; multicatalytic endopeptidase complex epsilon chain; proteasome beta 5 subunit; proteasome catalytic subunit 3; proteasome chain 6; proteasome epsilon chain; proteasome subunit MB1; proteasome subunit X; proteasome subunit, beta type, 5
 UniProt Protein Name    Proteasome subunit beta type-5
 UniProt Synonym Protein Names   
Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit X
 Protein Family    Proteasome
 UniProt Gene Name    PSMB5 [Similar Products]
 UniProt Synonym Gene Names    LMPX; MB1; X [Similar Products]
 UniProt Entry Name    PSB5_HUMAN
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 NCBI Summary for PSMB5    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for PSMB5    PSMB5: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway. Belongs to the peptidase T1B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Proteasome complex; EC 3.4.25.1

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: proteasome complex; nucleoplasm; proteasome core complex; centrosome; nucleus; cytosol

Molecular Function: threonine endopeptidase activity; protein binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; response to oxidative stress; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
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 Research Articles on PSMB5    1. Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSMB5 recombinant proteinPathways associated with PSMB5 recombinant protein
 Reference Product  PubMed Publications
 PSMB7 recombinant protein  >6 publications with PSMB5 and PSMB7
 PSMB1 recombinant protein  >5 publications with PSMB5 and PSMB1
 PSMA1 recombinant protein  >5 publications with PSMB5 and PSMA1
 PSMA4 recombinant protein  >1 publications with PSMB5 and PSMA4
 PSMC4 recombinant protein  >1 publications with PSMB5 and PSMC4
 PSMA2 recombinant protein  >1 publications with PSMB5 and PSMA2
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
Diseases associated with PSMB5 recombinant proteinOrgans/Tissues associated with PSMB5 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >7 publications with PSMB5 and Death
 Liver Diseases Antibodies  >5 publications with PSMB5 and Liver Diseases
 Inflammation Antibodies  >3 publications with PSMB5 and Inflammation
 Adenocarcinoma Antibodies  >2 publications with PSMB5 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with PSMB5 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >2 publications with PSMB5 and Breast Neoplasms
 Necrosis Antibodies  >2 publications with PSMB5 and Necrosis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with PSMB5 and Drug-Related Side Effects and Adverse Reactions
 Kidney Diseases Antibodies  >1 publications with PSMB5 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with PSMB5 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with PSMB5 and Blood
 Brain Antibodies  >7 publications with PSMB5 and Brain
 Liver Antibodies  >6 publications with PSMB5 and Liver
 Muscle Antibodies  >5 publications with PSMB5 and Muscle
 Eye Antibodies  >4 publications with PSMB5 and Eye
 Lung Antibodies  >4 publications with PSMB5 and Lung
 Bone Antibodies  >3 publications with PSMB5 and Bone
 Prostate Antibodies  >2 publications with PSMB5 and Prostate
 Kidney Antibodies  >2 publications with PSMB5 and Kidney
 Bone Marrow Antibodies  >2 publications with PSMB5 and Bone Marrow
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