WP_010903472.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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Molecular Weight
45,284 Da
NCBI Official Full Name
peptidase
UniProt Protein Name
Proteasome-activating nucleotidase 2
UniProt Synonym Protein Names
Proteasomal ATPase 2
UniProt Synonym Gene Names
UniProt Comments for pan2
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
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Pathways associated with pan2 recombinant protein
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