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PCMT1 recombinant protein :: Protein-L-Isoaspartate O-Methyltransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144034 PCMT1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein-L-Isoaspartate O-Methyltransferase (PCMT1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Protein-L-Isoaspartate O-Methyltransferase

 Product Synonym Names    PCMT1 Human; Protein-L-Isoaspartate O-Methyltransferase Human Recombinant; EC 2.1.1.77; PIMT; PCMT1; Protein-beta-aspartate methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; L-isoaspartyl protein carboxyl methyltransferase
 Product Gene Name   

PCMT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    RGSHHHH HH GMASMTGGQQ MGRDLYDDDD KDRWGS MAWK SGGASHSELI HNLRKNGIIK TDKVFEVMLA TDRSHYAKCN PYMDSPQSIG FQATISAPHM HAYALELLFD QLHEGAKALD VGSGSGILTA CFARMVGCTG KVIGIDHIKE LVDDSINNVR KDDPTLLSSG RVQLVVGDGR MGYAEEAPYD AIHVGAAAPV VPQALIDQLK PGGRLILPVG PAGGNQMLEQ YDKLQDGSIK MKPLMGVIYV PLTDKEKQWS RWK
 OMIM    176851
 3D Structure    ModBase 3D Structure for P22061
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    PCMT1 Human solution containing 20mM Tris-HCl pH-8, 0.1M NaCl, & 10% glycerol.
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 Source    Escherichia Coli.
 Physical Appearance    Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PCMT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PCMT1 recombinant protein

   Description: PCMT1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 263 amino acids (1-227 a.a.) and having a molecular mass of 28.8 kDa. The PCMT1 is fused to 36 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: PCMT1 enzyme catalyses the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. PCMT1 is involved in the repair and/or degradation of damaged proteins.
 Product Categories/Family for PCMT1 recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for PCMT1. It may not necessarily be applicable to this product.
 NCBI GI #    354983493
 NCBI GeneID    5110
 NCBI Accession #    NP_001238978.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001252049.1 [Other Products]
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 UniProt Primary Accession #    P22061 [Other Products]
 UniProt Secondary Accession #    Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; A8K109; J3KP72 [Other Products]
 UniProt Related Accession #    P22061 [Other Products]
 Molecular Weight    24,679 Da
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 NCBI Official Full Name    protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 2
 NCBI Official Synonym Full Names    protein-L-isoaspartate (D-aspartate) O-methyltransferase
 NCBI Official Symbol    PCMT1 [Similar Products]
 NCBI Official Synonym Symbols   
PIMT
[Similar Products]
 NCBI Protein Information    protein-L-isoaspartate(D-aspartate) O-methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase; L-isoaspartyl protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase; protein-beta-aspartate methyltransferase
 UniProt Protein Name    Protein-L-isoaspartate(D-aspartate) O-methyltransferase
 UniProt Synonym Protein Names   
L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase
 Protein Family    Protein-L-isoaspartate O-methyltransferase
 UniProt Gene Name    PCMT1 [Similar Products]
 UniProt Synonym Gene Names    PIMT [Similar Products]
 UniProt Entry Name    PIMT_HUMAN
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 NCBI Summary for PCMT1    This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for PCMT1    PCMT1: Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.77; Methyltransferase

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: endoplasmic reticulum; cytoplasm; vesicle

Molecular Function: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Biological Process: protein repair; protein amino acid methylation
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 Research Articles on PCMT1    1. ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with PCMT1 recombinant proteinOrgans/Tissues associated with PCMT1 recombinant protein
 Disease Name  Pubmed Publications
 Seizures Antibodies  >8 publications with PCMT1 and Seizures
 Brain Diseases Antibodies  >6 publications with PCMT1 and Brain Diseases
 Neural Tube Defects Antibodies  >3 publications with PCMT1 and Neural Tube Defects
 Death Antibodies  >3 publications with PCMT1 and Death
 Liver Diseases Antibodies  >2 publications with PCMT1 and Liver Diseases
 Congenital Abnormalities Antibodies  >2 publications with PCMT1 and Congenital Abnormalities
 Carcinoma, Hepatocellular Antibodies  >2 publications with PCMT1 and Carcinoma, Hepatocellular
 Immune System Diseases Antibodies  >2 publications with PCMT1 and Immune System Diseases
 Heart Diseases Antibodies  >1 publications with PCMT1 and Heart Diseases
 Fatty Liver Antibodies  >1 publications with PCMT1 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with PCMT1 and Brain
 Blood Antibodies  >5 publications with PCMT1 and Blood
 Liver Antibodies  >5 publications with PCMT1 and Liver
 Muscle Antibodies  >4 publications with PCMT1 and Muscle
 Heart Antibodies  >4 publications with PCMT1 and Heart
 Testis Antibodies  >2 publications with PCMT1 and Testis
 Kidney Antibodies  >1 publications with PCMT1 and Kidney
 Pancreas Antibodies  >1 publications with PCMT1 and Pancreas
 Eye Antibodies  >1 publications with PCMT1 and Eye
 Placenta Antibodies  >1 publications with PCMT1 and Placenta
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