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PTPRN recombinant protein :: Protein Tyrosine Phosphatase IA2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS636676
Test Data
Unit / Price
0.02 mg  /  $565 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein Tyrosine Phosphatase IA2 (PTPRN), Recombinant Protein

★Popular Item★
 Also Known As   

Protein Tyrosine Phosphatase IA2 (693-979), Recombinant, Human (PTP-IA2, ICA-512)

 Product Gene Name   

PTPRN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (220154345..220174295, complement). Location: 2q35-q36.1
 OMIM    601773
 3D Structure    ModBase 3D Structure for Q16849
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 Host    Recombinant, Human from E Coli
 Species Reactivity    Human
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 Purity/Purification    >=90%
 Form/Format    Supplied as a liquid in 25 Mm Tris-HCl, pH 8.0, 75 mM sodium chloride, 0.05% Tween-20, 2mM EDTA, 1mM DTT, 10mM glutathione, 50% glycerol.
 Concentration    2.16 mg/ml (lot specific)
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 Preparation and Storage    Store at -70 degree C. Stable for 6 months after receipt. For maximum recovery of product, centriuge the original vial after thawing and prior to removing the cap.
Shipping: Ships with Dry Ice.
 Other Notes    Small volumes of PTPRN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTPRN recombinant protein

   Recombinant protein corresponding to aa693-979 from human Protein Tyrosine Phosphate, with N-terminal GST tag, expressed in E.coli
 Product Categories/Family for PTPRN recombinant protein    Molecular Biology; MB-Enzymes, Phosphatase
 Application Notes for PTPRN recombinant protein    Suitable for the use as an immunogen, in binding assays or as an antigen in autoimmune assays. Other applications not tested.
Recommended Dilution: Optimal dilution to be determined by researcher.
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 Test Data of PTPRN recombinant protein    4-20% SDS-PAGE Coomassie Staining
PTPRN recombinant protein Test Data image
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NCBI/Uniprot data below describe general gene information for PTPRN. It may not necessarily be applicable to this product.
 NCBI GI #    39644800
 NCBI GeneID    5798
 NCBI Accession #    NM_002846 [Other Products]
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 UniProt Primary Accession #    Q16849 [Other Products]
 UniProt Secondary Accession #    Q08319; Q53QD6; Q6NSL1; B4DK12; F5GZS3 [Other Products]
 UniProt Related Accession #    Q16849 [Other Products]
 Molecular Weight    ~58.8kD [Similar Products]
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 NCBI Official Full Name    PTPRN protein, partial
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, N
 NCBI Official Symbol    PTPRN [Similar Products]
 NCBI Official Synonym Symbols   
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase-like N
 UniProt Synonym Protein Names   
Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Gene Name    PTPRN [Similar Products]
 UniProt Synonym Gene Names    ICA3; ICA512; R-PTP-N; ICA 512 [Similar Products]
 UniProt Entry Name    PTPRN_HUMAN
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 NCBI Summary for PTPRN    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
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 UniProt Comments for PTPRN    PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: integral to membrane

Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity

Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus
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 Research Articles on PTPRN    1. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPRN recombinant proteinPathways associated with PTPRN recombinant protein
 Reference Product  PubMed Publications
 PTPRT recombinant protein  >23 publications with PTPRN and PTPRT
 INS recombinant protein  >8 publications with PTPRN and INS
 PTPRS recombinant protein  >1 publications with PTPRN and PTPRS
 MADD recombinant protein  >1 publications with PTPRN and MADD
 GAD2 recombinant protein  >1 publications with PTPRN and GAD2
 Products by Pathway  Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
Diseases associated with PTPRN recombinant proteinOrgans/Tissues associated with PTPRN recombinant protein
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >190 publications with PTPRN and Autoimmune Diseases
 Immune System Diseases Antibodies  >189 publications with PTPRN and Immune System Diseases
 Neoplasms Antibodies  >14 publications with PTPRN and Neoplasms
 Nervous System Diseases Antibodies  >9 publications with PTPRN and Nervous System Diseases
 Disease Models, Animal Antibodies  >7 publications with PTPRN and Disease Models, Animal
 Brain Diseases Antibodies  >4 publications with PTPRN and Brain Diseases
 Kidney Diseases Antibodies  >3 publications with PTPRN and Kidney Diseases
 Weight Loss Antibodies  >2 publications with PTPRN and Weight Loss
 Inflammation Antibodies  >2 publications with PTPRN and Inflammation
 Liver Diseases Antibodies  >2 publications with PTPRN and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >130 publications with PTPRN and Pancreas
 Brain Antibodies  >29 publications with PTPRN and Brain
 Nerve Antibodies  >6 publications with PTPRN and Nerve
 Lung Antibodies  >6 publications with PTPRN and Lung
 Kidney Antibodies  >4 publications with PTPRN and Kidney
 Pituitary Gland Antibodies  >4 publications with PTPRN and Pituitary Gland
 Muscle Antibodies  >3 publications with PTPRN and Muscle
 Eye Antibodies  >3 publications with PTPRN and Eye
 Embryonic Tissue Antibodies  >2 publications with PTPRN and Embryonic Tissue
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