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PTPRN recombinant protein :: Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018571 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $275 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.2 mg  /  $525 +1 FREE 8GB USB
0.5 mg  /  $1,015 +1 FREE 8GB USB
1 mg  /  $1,515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein Tyrosine Phosphatase Receptor Type N (PTPRN), Recombinant Protein

 Also Known As   

Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN)

 Product Gene Name   

PTPRN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF- PKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQNV VGPALTFRIR HNEQNLSLAD VTQQAGLVKS ELEAQTGLQI LQTGVGQREE AAAVLPQTAH STSPMRSVLL TLVALAGVAG LLVALAVALC VRQHA
 Chromosome Location    Chromosome: 2; NC_000002.11 (220154345..220174295, complement). Location: 2q35-q36.1
 OMIM    601773
 3D Structure    ModBase 3D Structure for Q16849
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Pro368~Ala575 (Accession # Q16849) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of PTPRN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTPRN recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for PTPRN recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of PTPRN recombinant protein    PTPRN recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for PTPRN. It may not necessarily be applicable to this product.
 NCBI GI #    315113878
 NCBI GeneID    5798
 NCBI Accession #    NP_001186692.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199763.1 [Other Products]
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 UniProt Primary Accession #    Q16849 [Other Products]
 UniProt Secondary Accession #    Q08319; Q53QD6; Q6NSL1; B4DK12; F5GZS3 [Other Products]
 UniProt Related Accession #    Q16849 [Other Products]
 Molecular Weight    23.0kDa
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 NCBI Official Full Name    receptor-type tyrosine-protein phosphatase-like N isoform 2
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, N
 NCBI Official Symbol    PTPRN [Similar Products]
 NCBI Official Synonym Symbols   
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase-like N
 UniProt Synonym Protein Names   
Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Gene Name    PTPRN [Similar Products]
 UniProt Synonym Gene Names    ICA3; ICA512; R-PTP-N; ICA 512 [Similar Products]
 UniProt Entry Name    PTPRN_HUMAN
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 NCBI Summary for PTPRN    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
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 UniProt Comments for PTPRN    PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: integral to membrane

Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity

Biological Process: response to reactive oxygen species; response to cAMP; insulin secretion; response to estrogen stimulus; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus
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 Research Articles on PTPRN    1. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPRN recombinant proteinPathways associated with PTPRN recombinant protein
 Reference Product  PubMed Publications
 PTPRT recombinant protein  >23 publications with PTPRN and PTPRT
 INS recombinant protein  >8 publications with PTPRN and INS
 MADD recombinant protein  >1 publications with PTPRN and MADD
 PTPRS recombinant protein  >1 publications with PTPRN and PTPRS
 GAD2 recombinant protein  >1 publications with PTPRN and GAD2
 Products by Pathway  Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
Diseases associated with PTPRN recombinant proteinOrgans/Tissues associated with PTPRN recombinant protein
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >192 publications with PTPRN and Autoimmune Diseases
 Immune System Diseases Antibodies  >191 publications with PTPRN and Immune System Diseases
 Neoplasms Antibodies  >14 publications with PTPRN and Neoplasms
 Nervous System Diseases Antibodies  >9 publications with PTPRN and Nervous System Diseases
 Disease Models, Animal Antibodies  >7 publications with PTPRN and Disease Models, Animal
 Brain Diseases Antibodies  >4 publications with PTPRN and Brain Diseases
 Kidney Diseases Antibodies  >3 publications with PTPRN and Kidney Diseases
 Weight Loss Antibodies  >2 publications with PTPRN and Weight Loss
 Inflammation Antibodies  >2 publications with PTPRN and Inflammation
 Liver Diseases Antibodies  >2 publications with PTPRN and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >130 publications with PTPRN and Pancreas
 Brain Antibodies  >29 publications with PTPRN and Brain
 Nerve Antibodies  >6 publications with PTPRN and Nerve
 Lung Antibodies  >6 publications with PTPRN and Lung
 Kidney Antibodies  >4 publications with PTPRN and Kidney
 Pituitary Gland Antibodies  >4 publications with PTPRN and Pituitary Gland
 Muscle Antibodies  >3 publications with PTPRN and Muscle
 Eye Antibodies  >3 publications with PTPRN and Eye
 Embryonic Tissue Antibodies  >2 publications with PTPRN and Embryonic Tissue
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