NP_001081637.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
39.7 kDa
NCBI Official Full Name
protein Wnt-8
NCBI Official Synonym Full Names
wingless-type MMTV integration site family member 8A
NCBI Protein Information
protein Wnt-8
UniProt Protein Name
Protein Wnt-8
UniProt Synonym Gene Names
UniProt Entry Name
WNT8_XENLA
UniProt Comments for wnt8
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.
Product References and Citations for wnt8 recombinant protein
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.Christian J.L., McMahon J.A., McMahon A.P., Moon R.T.Development 111:1045-1055(1991)
Xwnt-8b
a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis.Cui Y., Brown J.D., Moon R.T., Christian J.L.Development 121:2177-2186(1995)
Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development.Christian J.L., Gavin B.J., McMahon A.P., Moon R.T.Dev. Biol. 143:230-234(1991)
Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.Cunliffe V., Smith J.C.EMBO J. 13:349-359(1994)
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., De Robertis E.M.Nature 397:707-710(1999)
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.Zhang X., Abreu J.G., Yokota C., Macdonald B.T., Singh S., Coburn K.L., Cheong S.M., Zhang M.M., Ye Q.Z., Hang H.C., Steen H., He X.Cell 149:1565-1577(2012)
Structural basis of Wnt recognition by Frizzled.Janda C.Y., Waghray D., Levin A.M., Thomas C., Garcia K.C.Science 337:59-64(2012)
Research Articles on wnt8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with wnt8 recombinant protein
Diseases associated with wnt8 recombinant protein
Organs/Tissues associated with wnt8 recombinant protein
|