NP_058923.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,467 Da
NCBI Official Full Name
protein-arginine deiminase type-4
NCBI Official Synonym Full Names
peptidyl arginine deiminase 4
NCBI Official Synonym Symbols
NCBI Protein Information
protein-arginine deiminase type-4
UniProt Protein Name
Protein-arginine deiminase type-4
UniProt Synonym Protein Names
PAD-R4; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV
UniProt Synonym Gene Names
NCBI Summary for Padi4
converts arginine residues to citrulline residues; may regulate intermediate filament proteins and intermediate filament-associated proteins in cells undergoing degenerative processes [RGD, Feb 2006]
UniProt Comments for Padi4
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 ().
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Diseases associated with Padi4 recombinant protein
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