NP_001086988.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
97,645 Da
NCBI Official Full Name
protein argonaute-2
NCBI Official Synonym Full Names
argonaute 2, RISC catalytic component L homeolog
NCBI Official Synonym Symbols
ago2; ago2.S; eif2c1; eif2c2; Argonaute2 [Similar Products]
NCBI Protein Information
protein argonaute-2
UniProt Protein Name
Protein argonaute-2
UniProt Synonym Protein Names
Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2
UniProt Synonym Gene Names
UniProt Comments for eif2c2
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur.
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Organs/Tissues associated with eif2c2 recombinant protein
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