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Crbn recombinant protein :: Protein cereblon (Crbn) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1387741 Crbn recombinant protein
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $860 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,085 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,155 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,275 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,375 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,810 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,975 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,015 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,600 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein cereblon (Crbn), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Protein cereblon (Crbn)

 Product Synonym Names    Protein cereblon; Protein PiL
 Product Gene Name   

Crbn recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1387741 COA    COA PDF
 Sequence Positions    1-445aa; full length protein
 Sequence    MAGEGDQQDA AHNMGNHLPL LPADSEDEDD EIEMEVEDQD SKEARKPNII NFDTSLPTSH TYLGADMEEF HGRTLHDDDS CQVIPVLPEV LMILIPGQTL PLQLSHPQEV SMVRNLIQKD RTFAVLAYSN VQEREAQFGT TAEIYAYREE QEFGIEVVKV KAIGRQRFKV LELRTQSDGI QQAKVQILPE CVLPSTMSAV QLESLNKCQV FPSKPISWED QYSCKWWQKY QKRKFHCANL TSWPRWLYSL YDAETLMDRI KKQLREWDEN LKDDSLPENP IDFSYRVAAC LPIDDVLRIQ LLKIGSAIQR LRCELDIMNK CTSLCCKQCQ ETEITTKNEI FSLSLCGPMA AYVNPHGYVH ETLTVYKASN LNLIGRPSTV HSWFPGYAWT IAQCKICASH IGWKFTATKK DMSPQKFWGL TRSALLPTIP ETEDEISPDK VILCL
 3D Structure    ModBase 3D Structure for Q8C7D2
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Crbn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Crbn. It may not necessarily be applicable to this product.
 NCBI GI #    90403612
 NCBI GeneID    58799
 NCBI Accession #    NP_067424.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021449.3 [Other Products]
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 UniProt Primary Accession #    Q8C7D2 [Other Products]
 UniProt Secondary Accession #    Q3TVC2; Q5RJV6; Q6IS49; Q80XJ1; Q8BP45; Q8C6B7; Q9JKR4 [Other Products]
 UniProt Related Accession #    Q8C7D2 [Other Products]
 Molecular Weight    50,809 Da
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 NCBI Official Full Name    protein cereblon isoform 1
 NCBI Official Synonym Full Names    cereblon
 NCBI Official Symbol    Crbn [Similar Products]
 NCBI Official Synonym Symbols   
piL; AF229032; AW108261; 2610203G15Rik; 2900045O07Rik
[Similar Products]
 NCBI Protein Information    protein cereblon; protein PiL; novel lethal
 UniProt Protein Name    Protein cereblon
 Protein Family    Protein cereblon
 UniProt Gene Name    Crbn [Similar Products]
 UniProt Synonym Gene Names    Protein PiL [Similar Products]
 UniProt Entry Name    CRBN_MOUSE
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 NCBI Summary for Crbn    This gene encodes a protein with a Lon protease domain, a "regulators of G protein-signaling" (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic mental retardation. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
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 UniProt Comments for Crbn    CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Cellular Component: membrane; cytoplasm; nucleolus; nucleus

Molecular Function: metal ion binding; ATP-dependent peptidase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; proteolysis; negative regulation of protein homooligomerization
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 Research Articles on Crbn    1. Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Crbn recombinant proteinDiseases associated with Crbn recombinant protein
 Reference Product  PubMed Publications
 Ddb1 recombinant protein  >9 publications with Crbn and Ddb1
 Cul4a recombinant protein  >5 publications with Crbn and Cul4a
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with Crbn and Nervous System Diseases
 Congenital Abnormalities Antibodies  >7 publications with Crbn and Congenital Abnormalities
 Mental Retardation, Autosomal Recessive 2 Antibodies  >7 publications with Crbn and Mental Retardation, Autosomal Recessive 2
 Abnormalities, Multiple Antibodies  >4 publications with Crbn and Abnormalities, Multiple
 Abnormalities, Drug-Induced Antibodies  >2 publications with Crbn and Abnormalities, Drug-Induced
 Learning Disorders Antibodies  >2 publications with Crbn and Learning Disorders
 Weight Gain Antibodies  >2 publications with Crbn and Weight Gain
 Fetal Death Antibodies  >2 publications with Crbn and Fetal Death
 Nervous System Malformations Antibodies  >1 publications with Crbn and Nervous System Malformations
 Weight Loss Antibodies  >1 publications with Crbn and Weight Loss
Organs/Tissues associated with Crbn recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with Crbn and Brain
 Bone Antibodies  >6 publications with Crbn and Bone
 Bone Marrow Antibodies  >6 publications with Crbn and Bone Marrow
 Prostate Antibodies  >2 publications with Crbn and Prostate
 Testis Antibodies  >1 publications with Crbn and Testis
 Liver Antibodies  >1 publications with Crbn and Liver
 Embryonic Tissue Antibodies  >1 publications with Crbn and Embryonic Tissue
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