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Prkci recombinant protein :: Protein kinase C iota type (Prkci) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1009498 Prkci recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,200 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,370 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,450 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,515 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,525 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,650 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,155 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,185 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,495 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,860 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein kinase C iota type (Prkci), Recombinant Protein

 Also Known As   

Recombinant Rat Protein kinase C iota type (Prkci)

 Product Gene Name   

Prkci recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-596aa, Full Length of Mature Protein
 Sequence    PTQRDSSTMS HTVACGGGGD HSHQVRVKAY YRGDIMITHF EPSISFEGLC SEVRDMCSFD NEQPFTMKWI DEEGDPCTVS SQLELEEAFR LYELNKDSEL LIHVFPCVPE RPGMPCPGED KSIYRRGARR WRKLYCANGH TFQAKRFNRR AHCAICTDRI WGLGRQGYKC INCKLLVHKK CHKLVTIECG RHSLPPEPMM PMDQSSMHPD HTQTVIPYNP SSHESLDQVG EEKEAMNTRE SGKASSSLGL QDFDLLRVIG RGSYAKVLLV RLKKTDRIYA MKVVKKELVN DDEDIDWVQT EKHVFEQASN HPFLVGLHSC FQTESRLFFV IEYVNGGDLM FHMQRQRKLP EEHARFYSAE ISLALNYLHE RGIIYRDLKL DNVLLDSEGH IKLTDYGMCK EGLRPGDTTS TFCGTPNYIA PEILRGEDYG FSVDWWALGV LMFEMMAGRS PFDIVGSSDN PDQNTEDYLF QVILEKQIRI PRSLSVKAAS VLKSFLNKDP KERLGCHPQT GFADIQGHPF FRNVDWDMME QKQVVPPFKP NISGEFGLDN FDSQFTNEPV QLTPDDDDIV RKIDQSEFEG FEYINPLLMS AEECV
 3D Structure    ModBase 3D Structure for F1M7Y5
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Prkci recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Prkci. It may not necessarily be applicable to this product.
 NCBI GI #    198041666
 NCBI GeneID    84006
 NCBI Accession #    NP_114448.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032059.1 [Other Products]
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 UniProt Primary Accession #    F1M7Y5 [Other Products]
 UniProt Secondary Accession #    B1PZT8 [Other Products]
 UniProt Related Accession #    F1M7Y5 [Other Products]
 Molecular Weight    68,276 Da
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 NCBI Official Full Name    protein kinase C iota type
 NCBI Official Synonym Full Names    protein kinase C, iota
 NCBI Official Symbol    Prkci [Similar Products]
 NCBI Official Synonym Symbols   
Pkcl
[Similar Products]
 NCBI Protein Information    protein kinase C iota type
 UniProt Protein Name    Protein kinase C iota type
 UniProt Synonym Protein Names   
Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; nPKC-iota
 Protein Family    Protein kinase
 UniProt Gene Name    Prkci [Similar Products]
 UniProt Synonym Gene Names    Pkcl; aPKC-lambda/iota [Similar Products]
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 NCBI Summary for Prkci    member of the atypical subgroup of PKCs that do not contain the calcium binding domain and possess only one cysteine-rich region; plays a critical role in controlling cell growth and cell survival; enhances Rab2-mediated vesicle budding [RGD, Feb 2006]
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 UniProt Comments for Prkci    Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Downstream of PI3K is required for insulin-stimulated glucose transport. Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes. Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity ().
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 Research Articles on Prkci    1. PKMzeta, but not PKCiota, knock-down disrupted previously established long-time memory. PKCiota and PKMz have distinct functions in long-term potentiation and memory, with PKMzeta playing a specific role in memory maintenance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Prkci recombinant proteinPathways associated with Prkci recombinant protein
 Reference Product  PubMed Publications
 Pard3 recombinant protein  >2 publications with Prkci and Pard3
 Products by Pathway  Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
Diseases associated with Prkci recombinant proteinOrgans/Tissues associated with Prkci recombinant protein
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >2 publications with Prkci and Neoplasm Metastasis
 Hyperplasia Antibodies  >1 publications with Prkci and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with Prkci and Breast Neoplasms
 Heart Failure Antibodies  >1 publications with Prkci and Heart Failure
 Kidney Diseases Antibodies  >1 publications with Prkci and Kidney Diseases
 Inflammation Antibodies  >1 publications with Prkci and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with Prkci and Brain
 Lung Antibodies  >3 publications with Prkci and Lung
 Prostate Antibodies  >3 publications with Prkci and Prostate
 Muscle Antibodies  >2 publications with Prkci and Muscle
 Kidney Antibodies  >1 publications with Prkci and Kidney
 Liver Antibodies  >1 publications with Prkci and Liver
 Ovary Antibodies  >1 publications with Prkci and Ovary
 Embryonic Tissue Antibodies  >1 publications with Prkci and Embryonic Tissue
 Colon Antibodies  >1 publications with Prkci and Colon
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