NP_001239160.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,010 Da
NCBI Official Full Name
protein transport protein Sec24A isoform 2
NCBI Official Synonym Full Names
SEC24 homolog A, COPII coat complex component
NCBI Protein Information
protein transport protein Sec24A
UniProt Protein Name
Protein transport protein Sec24A
UniProt Synonym Protein Names
SEC24-related protein A
NCBI Summary for SEC24A
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for SEC24A
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).
Research Articles on SEC24A
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Products associated with SEC24A recombinant protein
Pathways associated with SEC24A recombinant protein
Diseases associated with SEC24A recombinant protein
Organs/Tissues associated with SEC24A recombinant protein
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