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REL recombinant protein :: Proto-oncogene c-Rel Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265117 (PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed)
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proto-oncogene c-Rel, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Proto-oncogene c-Rel protein

 Product Gene Name   

REL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1265117 COA    COA PDF
 Sequence Positions    3-616aa; Partial
 Sequence    SGAYNPYIEI IEQPRQRGMR FRYKCEGRSA GSIPGEHSTD NNRTYPSIQI MNYYGKGKVR ITLVTKNDPY KPHPHDLVGK DCRDGYYEAE FGQERRPLFF QNLGIRCVKK KEVKEAIITR IKAGINPFNV PEKQLNDIED CDLNVVRLCF QVFLPDEHGN LTTALPPVVS NPIYDNRAPN TAELRICRVN KNCGSVRGGD EIFLLCDKVQ KDDIEVRFVL NDWEAKGIFS QADVHRQVAI VFKTPPYCKA ITEPVTVKMQ LRRPSDQEVS ESMDFRYLPD EKDTYGNKAK KQKTTLLFQK LCQDHVETGF RHVDQDGLEL LTSGDPPTLA SQSAGITVNF PERPRPGLLG SIGEGRYFKK EPNLFSHDAV VREMPTGVSS QAESYYPSPG PISSGLSHHA SMAPLPSSSW SSVAHPTPRS GNTNPLSSFS TRTLPSNSQG IPPFLRIPVG NDLNASNACI YNNADDIVGM EASSMPSADL YGISDPNMLS NCSVNMMTTS SDSMGETDNP RLLSMNLENP SCNSVLDPRD LRQLHQMSSS SMSAGANSNT TVFVSQSDAF EGSDFSCADN SMINESGPSN STNPNSHGFV QDSQYSGIGS MQNEQLSDSF PYEF
 OMIM    164910
 3D Structure    ModBase 3D Structure for Q04864
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of REL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for REL recombinant protein

   Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with mbers of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
 Product Categories/Family for REL recombinant protein    Transcription
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 SDS-PAGE of REL recombinant protein    REL recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for REL. It may not necessarily be applicable to this product.
 NCBI GI #    619534182
 NCBI GeneID    5966
 NCBI Accession #    NP_001278675.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291746.1 [Other Products]
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 UniProt Primary Accession #    Q04864 [Other Products]
 UniProt Secondary Accession #    Q17RU2; Q2PNZ7; Q6LDY0 [Other Products]
 UniProt Related Accession #    Q04864 [Other Products]
 Molecular Weight    72kD
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 NCBI Official Full Name    proto-oncogene c-Rel isoform 2
 NCBI Official Synonym Full Names    v-rel avian reticuloendotheliosis viral oncogene homolog
 NCBI Official Symbol    REL [Similar Products]
 NCBI Official Synonym Symbols   
C-Rel
[Similar Products]
 NCBI Protein Information    proto-oncogene c-Rel
 UniProt Protein Name    Proto-oncogene c-Rel
 Protein Family    Proto-oncogene
 UniProt Gene Name    REL [Similar Products]
 UniProt Entry Name    REL_HUMAN
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 NCBI Summary for REL    This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
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 UniProt Comments for REL    REL: a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 2p13-p12

Cellular Component: cytosol; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; transcription factor activity

Biological Process: cytokine production; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; response to cytokine stimulus; transcription from RNA polymerase II promoter
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Product References and Citations for REL recombinant protein

   A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.Brownell E., Mittereder N., Rice N.R.Oncogene 4:935-942(1989) NHLBI resequencing and genotyping service (RS&G) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005) Genetic characterization of human c-rel sequences.Brownell E., O'Brien S.J., Nash W.G., Rice N.R.Mol. Cell. Biol. 5:2826-2831(1985) A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.Hansen S.K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P.A., Blasi F.EMBO J. 11:205-213(1992) Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.Beg A.A., Baldwin A.S. Jr.Oncogene 9:1487-1492(1994) Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50.Aoudjit F., Brochu N., Belanger B., Stratowa C., Hiscott J., Audette M.Cell Growth Differ. 8:335-342(1997) A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65) -mediated NF-kappaB transcription.Li Z., Nabel G.J.Mol. Cell. Biol. 17:6184-6190(1997) Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel.Martin A.G., Fresno M.J. Biol. Chem. 275:24383-24391(2000) Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages involvement in cytokine synthesis.Guizani-Tabbane L., Ben-Aissa K., Belghith M., Sassi A., Dellagi K.Infect. Immun. 72:2582-2589(2004) Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras.Chen Y., Vallee S., Wu J., Vu D., Sondek J., Ghosh G.Mol. Cell. Biol. 24:3048-3056(2004) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012)
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 Research Articles on REL    1. c-Rel is a critical mediator of NF-kappaB-dependent TRAIL resistance of pancreatic cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with REL recombinant proteinPathways associated with REL recombinant protein
 Reference Product  PubMed Publications
 RELA recombinant protein  >738 publications with REL and RELA
 NFKB2 recombinant protein  >100 publications with REL and NFKB2
 CD40 recombinant protein  >95 publications with REL and CD40
 NFKB1 recombinant protein  >91 publications with REL and NFKB1
 FOXP3 recombinant protein  >31 publications with REL and FOXP3
 NFKBIE recombinant protein  >16 publications with REL and NFKBIE
 NFKBIA recombinant protein  >14 publications with REL and NFKBIA
 TBK1 recombinant protein  >4 publications with REL and TBK1
 MAPK8 recombinant protein  >3 publications with REL and MAPK8
 NFKBIB recombinant protein  >3 publications with REL and NFKBIB
 Products by Pathway  Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Signaling By The B Cell Receptor (BCR) Pathway antibodies  Signaling By The B Cell Receptor (BCR) Pathway Diagram
Diseases associated with REL recombinant proteinOrgans/Tissues associated with REL recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >479 publications with REL and Necrosis
 Inflammation Antibodies  >347 publications with REL and Inflammation
 Cell Transformation, Neoplastic Antibodies  >174 publications with REL and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >111 publications with REL and Disease Models, Animal
 Nervous System Diseases Antibodies  >102 publications with REL and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >99 publications with REL and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >61 publications with REL and Adenocarcinoma
 Lung Diseases Antibodies  >61 publications with REL and Lung Diseases
 Neoplasms, Experimental Antibodies  >59 publications with REL and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >56 publications with REL and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1030 publications with REL and Blood
 Lung Antibodies  >138 publications with REL and Lung
 Liver Antibodies  >134 publications with REL and Liver
 Brain Antibodies  >133 publications with REL and Brain
 Kidney Antibodies  >92 publications with REL and Kidney
 Embryonic Tissue Antibodies  >85 publications with REL and Embryonic Tissue
 Thymus Antibodies  >78 publications with REL and Thymus
 Lymph Node Antibodies  >50 publications with REL and Lymph Node
 Intestine Antibodies  >47 publications with REL and Intestine
 Lymph Antibodies  >44 publications with REL and Lymph
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