NP_002935.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
263,915 Da
NCBI Official Full Name
proto-oncogene tyrosine-protein kinase ROS
NCBI Official Synonym Full Names
ROS proto-oncogene 1, receptor tyrosine kinase
NCBI Protein Information
proto-oncogene tyrosine-protein kinase ROS
UniProt Protein Name
Proto-oncogene tyrosine-protein kinase ROS
UniProt Synonym Protein Names
Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase
UniProt Synonym Gene Names
NCBI Summary for ROS1
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for ROS1
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Research Articles on ROS1
Precautions
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Products associated with ROS1 recombinant protein
Diseases associated with ROS1 recombinant protein
Organs/Tissues associated with ROS1 recombinant protein
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