Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow SRC  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Cytochrome P450 19A1 (CYP19A1) Recombinant Protein
 • BMP-2 Antibody
 • TP53 ELISA Kit
 • Goat Anti-Rabbit IgG (H&L) HRP Secondary Antibody
 • NME1 Antibody
 • CD4 Antibody
 • Desmin Recombinant Protein
 • islet cell antibody, ICA (ical1) ELISA Kit
 • Galectin-3 (LGALS3) Recombinant Protein
 • Calnexin (CANX) Antibody
 • Hydroxyproline (HYP) ELISA Kit
 • Uveal Autoantigen With Coiled-Coil Domains and Ankyrin Repea... ELISA Kit
 • SBEM ELISA Kit
 • estradiol (E2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SRC recombinant protein :: Proto-oncogene tyrosine-protein kinase Src (SRC) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950013 SRC recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $960 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,390 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,405 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,420 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,465 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,575 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,015 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,100 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,115 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,395 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,755 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proto-oncogene tyrosine-protein kinase Src (SRC), Recombinant Protein

 Also Known As   

Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC)

 Product Gene Name   

SRC recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    2-536aa, Full Length of Mature Protein
 Sequence    GSNKSKPKDA SQRRRSLEPA ENVHGAGGGA FPASQTPSKP ASADGHRGPS AAFAPAAAEP KLFGGFNSSD TVTSPQRAGP LAGGVTTFVA LYDYESRTET DLSFKKGERL QIVNNTEGDW WLAHSLSTGQ TGYIPSNYVA PSDSIQAEEW YFGKITRRES ERLLLNAENP RGTFLVRESE TTKGAYCLSV SDFDNAKGLN VKHYKIRKLD SGGFYITSRT QFNSLQQLVA YYSKHADGLC HRLTTVCPTS KPQTQGLAKD AWEIPRESLR LEVKLGQGCF GEVWMGTWNG TTRVAIKTLK PGTMSPEAFL QEAQVMKKLR HEKLVQLYAV VSEEPIYIVT EYMSKGSLLD FLKGETGKYL RLPQLVDMAA QIASGMAYVE RMNYVHRDLR AANILVGENL VCKVADFGLA RLIEDNEYTA RQGAKFPIKW TAPEAALYGR FTIKSDVWSF GILLTELTTK GRVPYPGMVN REVLDQVERG YRMPCPPECP ESLHDLMCQC WRKEPEERPT FEYLQAFLED YFTSTEPQYQ PGENL
 OMIM    190090
 3D Structure    ModBase 3D Structure for P12931
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SRC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for SRC recombinant protein

   This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. This protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
NCBI/Uniprot data below describe general gene information for SRC. It may not necessarily be applicable to this product.
 NCBI GI #    4885609
 NCBI GeneID    6714
 NCBI Accession #    NP_005408.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005417.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P12931 [Other Products]
 UniProt Secondary Accession #    Q76P87; Q86VB9; Q9H5A8; E1P5V4 [Other Products]
 UniProt Related Accession #    P12931 [Other Products]
 Molecular Weight    60,589 Da
Table BarTOPTable Bar
 NCBI Official Full Name    proto-oncogene tyrosine-protein kinase Src
 NCBI Official Synonym Full Names    SRC proto-oncogene, non-receptor tyrosine kinase
 NCBI Official Symbol    SRC [Similar Products]
 NCBI Official Synonym Symbols   
ASV; SRC1; THC6; c-SRC; p60-Src
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase Src
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase Src
 UniProt Synonym Protein Names   
Proto-oncogene c-Src; pp60c-src; p60-Src
 Protein Family    Proto-oncogene tyrosine-protein kinase
 UniProt Gene Name    SRC [Similar Products]
 UniProt Synonym Gene Names    SRC1; p60-Src [Similar Products]
Section Bar
 NCBI Summary for SRC    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for SRC    Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation ().
Table BarTOPTable Bar
 Research Articles on SRC    1. We provide evidence here that Rab7 is a substrate of Src kinase, and is tyrosine-phosphorylated by Src, withY183 residue of Rab7 being the optimal phosphorylation site for Src. Further investigations demonstrated that the tyrosine phosphorylation of Rab7 depends on the guanine nucleotide binding activity of Rab7 and the activity of Src kinase.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SRC recombinant proteinPathways associated with SRC recombinant protein
 Reference Product  PubMed Publications
 CSK recombinant protein  >1280 publications with SRC and CSK
 GRB2 recombinant protein  >1156 publications with SRC and GRB2
 EGFR recombinant protein  >1076 publications with SRC and EGFR
 BCR recombinant protein  >833 publications with SRC and BCR
 PTK2 recombinant protein  >574 publications with SRC and PTK2
 CBL recombinant protein  >466 publications with SRC and CBL
 ERBB2 recombinant protein  >357 publications with SRC and ERBB2
 MET recombinant protein  >334 publications with SRC and MET
 CTNNB1 recombinant protein  >309 publications with SRC and CTNNB1
 FGR recombinant protein  >284 publications with SRC and FGR
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
Diseases associated with SRC recombinant proteinOrgans/Tissues associated with SRC recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6063 publications with SRC and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1864 publications with SRC and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >925 publications with SRC and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >707 publications with SRC and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >695 publications with SRC and Disease Models, Animal
 Inflammation Antibodies  >677 publications with SRC and Inflammation
 Cardiovascular Diseases Antibodies  >675 publications with SRC and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >596 publications with SRC and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >517 publications with SRC and Neoplasm Metastasis
 Necrosis Antibodies  >516 publications with SRC and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4805 publications with SRC and Blood
 Brain Antibodies  >1859 publications with SRC and Brain
 Muscle Antibodies  >1471 publications with SRC and Muscle
 Bone Antibodies  >1198 publications with SRC and Bone
 Kidney Antibodies  >1056 publications with SRC and Kidney
 Nerve Antibodies  >1002 publications with SRC and Nerve
 Lung Antibodies  >872 publications with SRC and Lung
 Liver Antibodies  >785 publications with SRC and Liver
 Embryonic Tissue Antibodies  >507 publications with SRC and Embryonic Tissue
 Prostate Antibodies  >425 publications with SRC and Prostate
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions