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SRC recombinant protein :: Proto-oncogene tyrosine-protein kinase Src (SRC) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950013 SRC recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $960 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,025 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,390 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,405 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,420 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,465 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,575 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,015 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,100 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,115 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,395 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,755 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proto-oncogene tyrosine-protein kinase Src (SRC), Recombinant Protein

 Also Known As   

Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC)

 Product Synonym Names    Proto-oncogene tyrosine-protein kinase Src; EC=2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-Src
 Product Gene Name   

SRC recombinant protein

[Similar Products]
 Product Synonym Gene Name    SRC; SRC1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-536. Full-length.
 Sequence    GSNKSKPKDA SQRRRSLEPA ENVHGAGGGA FPASQTPSKP ASADGHRGPS AAFAPAAAEP KLFGGFNSSD TVTSPQRAGP LAGGVTTFVA LYDYESRTET DLSFKKGERL QIVNNTEGDW WLAHSLSTGQ TGYIPSNYVA PSDSIQAEEW YFGKITRRES ERLLLNAENP RGTFLVRESE TTKGAYCLSV SDFDNAKGLN VKHYKIRKLD SGGFYITSRT QFNSLQQLVA YYSKHADGLC HRLTTVCPTS KPQTQGLAKD AWEIPRESLR LEVKLGQGCF GEVWMGTWNG TTRVAIKTLK PGTMSPEAFL QEAQVMKKLR HEKLVQLYAV VSEEPIYIVT EYMSKGSLLD FLKGETGKYL RLPQLVDMAA QIASGMAYVE RMNYVHRDLR AANILVGENL VCKVADFGLA RLIEDNEYTA RQGAKFPIKW TAPEAALYGR FTIKSDVWSF GILLTELTTK GRVPYPGMVN REVLDQVERG YRMPCPPECP ESLHDLMCQC WRKEPEERPT FEYLQAFLED YFTSTEPQYQ PGENL
 OMIM    190090
 3D Structure    ModBase 3D Structure for P12931
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SRC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SRC recombinant protein

   This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. This protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
NCBI/Uniprot data below describe general gene information for SRC. It may not necessarily be applicable to this product.
 NCBI GI #    4885609
 NCBI GeneID    6714
 NCBI Accession #    NP_005408.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005417.4 [Other Products]
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 UniProt Primary Accession #    P12931 [Other Products]
 UniProt Secondary Accession #    Q76P87; Q86VB9; Q9H5A8; E1P5V4 [Other Products]
 UniProt Related Accession #    P12931 [Other Products]
 Molecular Weight    60,589 Da
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 NCBI Official Full Name    proto-oncogene tyrosine-protein kinase Src
 NCBI Official Synonym Full Names    SRC proto-oncogene, non-receptor tyrosine kinase
 NCBI Official Symbol    SRC [Similar Products]
 NCBI Official Synonym Symbols   
ASV; SRC1; c-SRC; p60-Src
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase Src
 UniProt Synonym Protein Names   
Proto-oncogene c-Src; pp60c-src; p60-Src
 Protein Family    Proto-oncogene tyrosine-protein kinase
 UniProt Gene Name    SRC [Similar Products]
 UniProt Synonym Gene Names    SRC1; p60-Src [Similar Products]
 UniProt Entry Name    SRC_HUMAN
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 NCBI Summary for SRC    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SRC    Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described.

Protein type: Oncoprotein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q12-q13

Cellular Component: neuron projection; mitochondrion; lysosome; postsynaptic density; actin filament; caveola; cytosol; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; late endosome; mitochondrial inner membrane; plasma membrane; nucleus

Molecular Function: protein C-terminus binding; ephrin receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; insulin receptor binding; protein kinase activity; integrin binding; protein binding; enzyme binding; SH3/SH2 adaptor activity; protein kinase C binding; protein-tyrosine kinase activity; heme binding; estrogen receptor binding; SH2 domain binding; kinase activity; ATP binding; receptor binding; hormone receptor binding

Biological Process: oogenesis; regulation of estrogen receptor signaling pathway; estrogen receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; central nervous system development; progesterone receptor signaling pathway; viral reproduction; nerve growth factor receptor signaling pathway; regulation of cell cycle; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; uterus development; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; positive regulation of MAP kinase activity; cell-cell adhesion; transforming growth factor beta receptor signaling pathway; cell adhesion; response to electrical stimulus; bone resorption; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; activation of protein kinase B; response to virus; transcytosis; positive regulation of integrin activation; positive regulation of protein amino acid autophosphorylation; cellular response to insulin stimulus; response to mechanical stimulus; T cell costimulation; regulation of vascular permeability; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of apoptosis; axon guidance; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; negative regulation of caspase activity; positive regulation of smooth muscle cell migration; signal transduction; regulation of cell-cell adhesion; forebrain development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; response to nutrient levels; integrin-mediated signaling pathway; regulation of bone resorption; negative regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; signal complex assembly; response to mineralocorticoid stimulus; cell cycle; regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; response to hydrogen peroxide; regulation of protein binding; Ras protein signal transduction; stress fiber formation; innate immune response; response to acidity; positive regulation of insulin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cytokine secretion
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 Research Articles on SRC    1. Cx43 regulates c-Src activity and proliferation in human glioma stem cell.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SRC recombinant proteinPathways associated with SRC recombinant protein
 Reference Product  PubMed Publications
 CSK recombinant protein  >1280 publications with SRC and CSK
 GRB2 recombinant protein  >1156 publications with SRC and GRB2
 EGFR recombinant protein  >1076 publications with SRC and EGFR
 BCR recombinant protein  >833 publications with SRC and BCR
 PTK2 recombinant protein  >574 publications with SRC and PTK2
 CBL recombinant protein  >466 publications with SRC and CBL
 ERBB2 recombinant protein  >357 publications with SRC and ERBB2
 MET recombinant protein  >334 publications with SRC and MET
 CTNNB1 recombinant protein  >309 publications with SRC and CTNNB1
 FGR recombinant protein  >284 publications with SRC and FGR
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
Diseases associated with SRC recombinant proteinOrgans/Tissues associated with SRC recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6063 publications with SRC and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1864 publications with SRC and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >925 publications with SRC and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >707 publications with SRC and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >695 publications with SRC and Disease Models, Animal
 Inflammation Antibodies  >677 publications with SRC and Inflammation
 Cardiovascular Diseases Antibodies  >675 publications with SRC and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >596 publications with SRC and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >517 publications with SRC and Neoplasm Metastasis
 Necrosis Antibodies  >516 publications with SRC and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4805 publications with SRC and Blood
 Brain Antibodies  >1859 publications with SRC and Brain
 Muscle Antibodies  >1471 publications with SRC and Muscle
 Bone Antibodies  >1198 publications with SRC and Bone
 Kidney Antibodies  >1056 publications with SRC and Kidney
 Nerve Antibodies  >1002 publications with SRC and Nerve
 Lung Antibodies  >872 publications with SRC and Lung
 Liver Antibodies  >785 publications with SRC and Liver
 Embryonic Tissue Antibodies  >507 publications with SRC and Embryonic Tissue
 Prostate Antibodies  >425 publications with SRC and Prostate
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