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SFTPC recombinant protein :: Pulmonary surfactant-associated protein C Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS963062
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.01 mg (Mammalian-Cell)  /  $205 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.02 mg (Mammalian-Cell)  /  $295 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $575 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $770 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $795 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $975 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,410 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $1,895 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pulmonary surfactant-associated protein C (SFTPC), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Pulmonary surfactant-associated protein C

 Product Synonym Names    Pulmonary surfactant-associated proteolipid SPL(Val); SP5
 Product Gene Name   

SFTPC recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-58aa; Full Length
 Sequence    FGIPCCPVHL KRLLIVVVVV VLIVVVIVGA LLMGL
 OMIM    178620
 3D Structure    ModBase 3D Structure for P11686
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SFTPC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SFTPC recombinant protein

   Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
 Product Categories/Family for SFTPC recombinant protein    Cancer
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 SDS-PAGE of SFTPC recombinant protein    SFTPC recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for SFTPC. It may not necessarily be applicable to this product.
 NCBI GI #    288915543
 NCBI GeneID    6440
 NCBI Accession #    NP_001165828.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172357.1 [Other Products]
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 UniProt Primary Accession #    P11686 [Other Products]
 UniProt Secondary Accession #    P11687; Q12793; Q7Z5D0; A6XNE4; B2RE00; E9PGX3 [Other Products]
 UniProt Related Accession #    P11686 [Other Products]
 Molecular Weight    30.39kD
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 NCBI Official Full Name    pulmonary surfactant-associated protein C isoform 2
 NCBI Official Synonym Full Names    surfactant protein C
 NCBI Official Symbol    SFTPC [Similar Products]
 NCBI Official Synonym Symbols   
SP-C; PSP-C; SFTP2; SMDP2; BRICD6
[Similar Products]
 NCBI Protein Information    pulmonary surfactant-associated protein C
 UniProt Protein Name    Pulmonary surfactant-associated protein C
 UniProt Synonym Protein Names   
Pulmonary surfactant-associated proteolipid SPL(Val); SP5
 Protein Family    Pulmonary surfactant-associated protein
 UniProt Gene Name    SFTPC [Similar Products]
 UniProt Synonym Gene Names    SFTP2; SP-C [Similar Products]
 UniProt Entry Name    PSPC_HUMAN
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 NCBI Summary for SFTPC    This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]
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 UniProt Comments for SFTPC    SFTPC: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. Defects in SFTPC are the cause of pulmonary surfactant metabolism dysfunction type 2 (SMDP2); also called pulmonary alveolar proteinosis due to surfactant protein C deficiency. A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPC are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: clathrin-coated endocytic vesicle; endoplasmic reticulum membrane; extracellular region; extracellular space; lamellar body

Molecular Function: protein binding

Biological Process: cellular protein metabolic process; respiratory gaseous exchange

Disease: Pulmonary Fibrosis, Idiopathic; Surfactant Metabolism Dysfunction, Pulmonary, 2
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Product References and Citations for SFTPC recombinant protein

   "Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences." Warr R.G., Hawgood S., Buckley D.I., Crisp T.M., Schilling J., Benson B.J., Ballard P.L., Clements J.A., White R.T. Proc. Natl. Acad. Sci. U.S.A. 84:7915-7919(1987)
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 Research Articles on SFTPC    1. support a chaperone function of the BRICHOS domain, possibly together with the linker region, during pro-SP-C biosynthesis in the endoplasmic reticulum
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SFTPC recombinant proteinPathways associated with SFTPC recombinant protein
 Reference Product  PubMed Publications
 ABCA3 recombinant protein  >38 publications with SFTPC and ABCA3
 SFTPB recombinant protein  >31 publications with SFTPC and SFTPB
 SCGB1A1 recombinant protein  >21 publications with SFTPC and SCGB1A1
 AQP5 recombinant protein  >13 publications with SFTPC and AQP5
 NKX2-1 recombinant protein  >12 publications with SFTPC and NKX2-1
 SFTPA2 recombinant protein  >11 publications with SFTPC and SFTPA2
 SFTPA1 recombinant protein  >6 publications with SFTPC and SFTPA1
 SFTPD recombinant protein  >5 publications with SFTPC and SFTPD
 DNAJB9 recombinant protein  >1 publications with SFTPC and DNAJB9
 DNAJC10 recombinant protein  >1 publications with SFTPC and DNAJC10
 Products by Pathway  Pathway Diagram
 ABC Transporter Disorders Pathway antibodies  ABC Transporter Disorders Pathway Diagram
 Defective ABCA3 Causes Pulmonary Surfactant Metabolism Dysfunction Type 3 (SMDP3) Pathway antibodies  Defective ABCA3 Causes Pulmonary Surfactant Metabolism Dysfunction Type 3 (SMDP3) Pathway Diagram
 Defective CSF2RA Causes Pulmonary Surfactant Metabolism Dysfunction 4 (SMDP4) Pathway antibodies  Defective CSF2RA Causes Pulmonary Surfactant Metabolism Dysfunction 4 (SMDP4) Pathway Diagram
 Defective CSF2RB Causes Pulmonary Surfactant Metabolism Dysfunction 5 (SMDP5) Pathway antibodies  Defective CSF2RB Causes Pulmonary Surfactant Metabolism Dysfunction 5 (SMDP5) Pathway Diagram
 Defective Pro-SFTPC Causes Pulmonary Surfactant Metabolism Dysfunction 2 (SMDP2) And Respiratory Distress Syndrome (RDS) Pathway antibodies  Defective Pro-SFTPC Causes Pulmonary Surfactant Metabolism Dysfunction 2 (SMDP2) And Respiratory Distress Syndrome (RDS) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Surfactant Metabolism Pathway antibodies  Diseases Associated With Surfactant Metabolism Pathway Diagram
 Diseases Of Metabolism Pathway antibodies  Diseases Of Metabolism Pathway Diagram
 Disorders Of Transmembrane Transporters Pathway antibodies  Disorders Of Transmembrane Transporters Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with SFTPC recombinant proteinOrgans/Tissues associated with SFTPC recombinant protein
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >155 publications with SFTPC and Lung Diseases
 Fibrosis Antibodies  >55 publications with SFTPC and Fibrosis
 Lung Injury Antibodies  >48 publications with SFTPC and Lung Injury
 Pneumonia Antibodies  >35 publications with SFTPC and Pneumonia
 Idiopathic Pulmonary Fibrosis Antibodies  >29 publications with SFTPC and Idiopathic Pulmonary Fibrosis
 Inflammation Antibodies  >26 publications with SFTPC and Inflammation
 Lung Neoplasms Antibodies  >17 publications with SFTPC and Lung Neoplasms
 Hyperplasia Antibodies  >12 publications with SFTPC and Hyperplasia
 Necrosis Antibodies  >6 publications with SFTPC and Necrosis
 Congenital Abnormalities Antibodies  >5 publications with SFTPC and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >257 publications with SFTPC and Lung
 Heart Antibodies  >10 publications with SFTPC and Heart
 Kidney Antibodies  >7 publications with SFTPC and Kidney
 Brain Antibodies  >6 publications with SFTPC and Brain
 Intestine Antibodies  >4 publications with SFTPC and Intestine
 Connective Tissue Antibodies  >3 publications with SFTPC and Connective Tissue
 Ovary Antibodies  >2 publications with SFTPC and Ovary
 Nerve Antibodies  >2 publications with SFTPC and Nerve
 Eye Antibodies  >1 publications with SFTPC and Eye
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