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Pdk1 recombinant protein :: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (Pdk1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1317979
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $820 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,055 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,100 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,215 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,245 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,305 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,340 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,410 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,925 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,970 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,140 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,535 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (Pdk1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (Pdk1)

 Product Gene Name   

Pdk1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Pdk1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1317979 COA    COA PDF
 Sequence Positions    27-434aa, Full Length of Mature Protein
 Sequence    ASASASGSGP ASELGVPGQV DFYARFSPSP LSMKQFLDFG SVNACEKTSF MFLRQELPVR LANIMKEISL LPDNLLRTPS VQLVQSWYIQ SLQELLDFKD KSAEDAKTIY EFTDTVIRIR NRHNDVIPTM AQGVTEYKES FGVDPVTSQN VQYFLDRFYM SRISIRMLLN QHSLLFGGKG SPSHRKHIGS INPNCDVVEV IKDGYENARR LCDLYYVNSP ELELEELNAK SPGQTIQVVY VPSHLYHMVF ELFKNAMRAT MEHHADKGVY PPIQVHVTLG EEDLTVKMSD RGGGVPLRKI DRLFNYMYST APRPRVETSR AVPLAGFGYG LPISRLYAQY FQGDLKLYSL EGYGTDAVIY IKALSTESVE RLPVYNKAAW KHYKANHEAD DWCVPSREPK DMTTFRSS
 3D Structure    ModBase 3D Structure for Q8BFP9
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Pdk1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Pdk1 recombinant protein

   Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation
dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.
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 SDS-Page of Pdk1 recombinant protein    Pdk1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Pdk1. It may not necessarily be applicable to this product.
 NCBI GI #    110625975
 NCBI GeneID    228026
 NCBI Accession #    NP_766253.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_172665.5 [Other Products]
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 UniProt Primary Accession #    Q8BFP9 [Other Products]
 UniProt Secondary Accession #    Q3U5E5 [Other Products]
 UniProt Related Accession #    Q8BFP9 [Other Products]
 Molecular Weight    48,995 Da
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 NCBI Official Full Name    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1
 NCBI Official Synonym Full Names    pyruvate dehydrogenase kinase, isoenzyme 1
 NCBI Official Symbol    Pdk1 [Similar Products]
 NCBI Official Synonym Symbols   
B830012B01; D530020C15Rik
[Similar Products]
 NCBI Protein Information    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase, isozyme 1
 UniProt Protein Name    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
 UniProt Synonym Protein Names   
Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1
 Protein Family    [Pyruvate dehydrogenase
 UniProt Gene Name    Pdk1 [Similar Products]
 UniProt Synonym Gene Names    PDH kinase 1 [Similar Products]
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 UniProt Comments for Pdk1    Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress ().
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 Research Articles on Pdk1    1. Here, the authors show that loss of Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Pdk1 recombinant proteinDiseases associated with Pdk1 recombinant protein
 Products by Pathway  Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway antibodies  PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >160 publications with Pdk1 and Neoplasms
 Insulin Resistance Antibodies  >30 publications with Pdk1 and Insulin Resistance
 Breast Neoplasms Antibodies  >29 publications with Pdk1 and Breast Neoplasms
 Inflammation Antibodies  >25 publications with Pdk1 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >23 publications with Pdk1 and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >21 publications with Pdk1 and Brain Diseases
 Disease Models, Animal Antibodies  >19 publications with Pdk1 and Disease Models, Animal
 Necrosis Antibodies  >19 publications with Pdk1 and Necrosis
 Hyperglycemia Antibodies  >17 publications with Pdk1 and Hyperglycemia
 Lung Neoplasms Antibodies  >17 publications with Pdk1 and Lung Neoplasms
Organs/Tissues associated with Pdk1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >88 publications with Pdk1 and Blood
 Muscle Antibodies  >86 publications with Pdk1 and Muscle
 Brain Antibodies  >51 publications with Pdk1 and Brain
 Heart Antibodies  >44 publications with Pdk1 and Heart
 Kidney Antibodies  >36 publications with Pdk1 and Kidney
 Lung Antibodies  >25 publications with Pdk1 and Lung
 Liver Antibodies  >25 publications with Pdk1 and Liver
 Pancreas Antibodies  >15 publications with Pdk1 and Pancreas
 Embryonic Tissue Antibodies  >14 publications with Pdk1 and Embryonic Tissue
 Ovary Antibodies  >12 publications with Pdk1 and Ovary
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