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QPCT recombinant protein

Scan QR to view Datasheet Catalog #    MBS206332
SDS-Page
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

QPCT, Recombinant Protein

★Popular Item★
 Also Known As   

QPCT, 29-361aa, Human, His tag, Baculovirus

 Product Synonym Names    Glutaminyl-peptide cyclotransferase; GCT; QC; sQC
 Product Gene Name   

QPCT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    VSPSASAWPE EKNYHQPAIL NSSALRQIAE GTSISEMWQN DLQPLLIERY PGSPGSYAAR QHIMQRIQRL QADWVLEIDT FLSQTPYGYR SFSNIISTLN PTAKRHLVLA CHYDSKYFSH WNNRVFVGAT DSAVPCAMML ELARALDKKL LSLKTVSDSK PDLSLQLIFF DGEEAFLHWS PQDSLYGSRH LAAKMASTPH PPGARGTSQL HGMDLLVLLD LIGAPNPTFP NFFPNSARWF ERLQAIEHEL HELGLLKDHS LEGRYFQNYS YGGVIQDDHI PFLRRGVPVL HLIPSPFPEV WHTMDDNEEN LDESTIDNLN KILQVFVLEY LHLHHHHHH
 OMIM    X71125 mRNA
 3D Structure    ModBase 3D Structure for Q16769
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 Host    Baculovirus
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
 Concentration    0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of QPCT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for QPCT recombinant protein

   QPCT, also known as glutaminyl-peptide cyclotransferase, is responsible for the biosynthesis of pyroglutamyl peptides. This protein has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It catalyzes N-terminal pyroglutamate formation. In vitro, it catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. Recombinant human QPCT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
 Product Categories/Family for QPCT recombinant protein    Neuroscience
 Applications Tested/Suitable for QPCT recombinant protein   

SDS-PAGE

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 SDS-Page of QPCT recombinant protein    QPCT recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for QPCT. It may not necessarily be applicable to this product.
 NCBI GI #    6912618
 NCBI GeneID    25797
 NCBI Accession #    NP_036545 [Other Products]
 NCBI GenBank Nucleotide #    NM_012413.3 [Other Products]
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 UniProt Primary Accession #    Q16769 [Other Products]
 UniProt Secondary Accession #    Q16770; Q3KRG6; Q53TR4 [Other Products]
 UniProt Related Accession #    Q16769 [Other Products]
 Molecular Weight    38.7kDa (339aa) 28-40kDa (SDS-PAGE under reducing conditions)
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 NCBI Official Full Name    glutaminyl-peptide cyclotransferase
 NCBI Official Synonym Full Names    glutaminyl-peptide cyclotransferase
 NCBI Official Symbol    QPCT [Similar Products]
 NCBI Official Synonym Symbols   
QC; GCT; sQC
[Similar Products]
 NCBI Protein Information    glutaminyl-peptide cyclotransferase
 UniProt Protein Name    Glutaminyl-peptide cyclotransferase
 UniProt Synonym Protein Names   
Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC
 UniProt Gene Name    QPCT [Similar Products]
 UniProt Synonym Gene Names    QC; sQC; EC [Similar Products]
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 NCBI Summary for QPCT    This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
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 UniProt Comments for QPCT    Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
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Product References and Citations for QPCT recombinant protein

   Schilling S. et al., (2004) FEBS Lett. 563:191-196.; Huang K.F. et al., (2011) J. Biol. Chem. 286:12439-12449.
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 Research Articles on QPCT    1. The addition of QC activity to core diagnostic CSF biomarkers may be of specific interest in clinical cases with discordant imaging and biochemical biomarker results.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with QPCT recombinant proteinDiseases associated with QPCT recombinant protein
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with QPCT and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with QPCT and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >2 publications with QPCT and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with QPCT and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with QPCT and Neoplasms, Experimental
 Hypertension Antibodies  >1 publications with QPCT and Hypertension
 Cognition Disorders Antibodies  >1 publications with QPCT and Cognition Disorders
 Kidney Diseases Antibodies  >1 publications with QPCT and Kidney Diseases
 Fibrosis Antibodies  >1 publications with QPCT and Fibrosis
 Hyperplasia Antibodies  >1 publications with QPCT and Hyperplasia
Organs/Tissues associated with QPCT recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with QPCT and Brain
 Thyroid Antibodies  >4 publications with QPCT and Thyroid
 Bone Antibodies  >3 publications with QPCT and Bone
 Blood Antibodies  >2 publications with QPCT and Blood
 Pituitary Gland Antibodies  >2 publications with QPCT and Pituitary Gland
 Eye Antibodies  >1 publications with QPCT and Eye
 Intestine Antibodies  >1 publications with QPCT and Intestine
 Kidney Antibodies  >1 publications with QPCT and Kidney
 Lung Antibodies  >1 publications with QPCT and Lung
 Connective Tissue Antibodies  >1 publications with QPCT and Connective Tissue
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