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QPRT recombinant protein

Scan QR to view Datasheet Catalog #    MBS203645
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

QPRT, Recombinant Protein

★Popular Item★
 Also Known As   

QPRT, 1-297aa, Human, His tag, E Coli

 Product Synonym Names    Nicotinate nucleotide pyrophosphorylase (carboxylating); Nicotinate nucleotide pyrophosphorylase carboxylating; Quinolinate phosphoribosyltransferase; QPRTase; QAPRTase
 Product Gene Name   

QPRT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH
 OMIM    D78177 mRNA
 3D Structure    ModBase 3D Structure for Q15274
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol
 Concentration    1mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of QPRT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for QPRT recombinant protein

   Quinolinate phosphoribosyltransferase, also known as QPRT, is a major enzyme in the catabolism of quinolinate. It is an intermediate in the tryptophannicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide and pyrophosphate. Elevation of QPRT levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Recombinant human QPRT protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for QPRT recombinant protein    Neuroscience
 Applications Tested/Suitable for QPRT recombinant protein   

SDS-PAGE

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 SDS-Page of QPRT recombinant protein    QPRT recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for QPRT. It may not necessarily be applicable to this product.
 NCBI GI #    45269149
 NCBI GeneID    23475
 NCBI Accession #    NP_055113 [Other Products]
 NCBI GenBank Nucleotide #    NM_014298.4 [Other Products]
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 UniProt Primary Accession #    Q15274 [Other Products]
 UniProt Secondary Accession #    Q53XW7; Q96G22; Q9BSG6 [Other Products]
 UniProt Related Accession #    Q15274 [Other Products]
 Molecular Weight    32.9 kDa (317aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    nicotinate-nucleotide pyrophosphorylase
 NCBI Official Synonym Full Names    quinolinate phosphoribosyltransferase
 NCBI Official Symbol    QPRT [Similar Products]
 NCBI Official Synonym Symbols   
QPRTase; HEL-S-90n
[Similar Products]
 NCBI Protein Information    nicotinate-nucleotide pyrophosphorylase [carboxylating]
 UniProt Protein Name    Nicotinate-nucleotide pyrophosphorylase [carboxylating]
 UniProt Synonym Protein Names   
Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
 Protein Family    Nicotinate-nucleotide pyrophosphorylase
 UniProt Gene Name    QPRT [Similar Products]
 UniProt Synonym Gene Names    QAPRTase; QPRTase [Similar Products]
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 NCBI Summary for QPRT    This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for QPRT    Involved in the catabolism of quinolinic acid (QA).
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Product References and Citations for QPRT recombinant protein

   Delaney J., et al. (2005) Arch Toxicol. 79 (2):208-223.; Eads J C., et al. (1997) Structure. 5:47-58.;
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 Research Articles on QPRT    1. WT1 knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 binding to a conserved site in the first intron of the QPRT gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with QPRT recombinant proteinDiseases associated with QPRT recombinant protein
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 NAD De Novo Biosynthesis Pathway antibodies  NAD De Novo Biosynthesis Pathway Diagram
 NAD+ Biosynthetic Pathways antibodies  NAD+ Biosynthetic Pathways Diagram
 Disease Name  Pubmed Publications
 Cognition Disorders Antibodies  >2 publications with QPRT and Cognition Disorders
 Chromosome Aberrations Antibodies  >1 publications with QPRT and Chromosome Aberrations
 Nerve Degeneration Antibodies  >1 publications with QPRT and Nerve Degeneration
 Kidney Diseases Antibodies  >1 publications with QPRT and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with QPRT and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with QPRT and Inflammation
Organs/Tissues associated with QPRT recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with QPRT and Brain
 Liver Antibodies  >11 publications with QPRT and Liver
 Blood Antibodies  >7 publications with QPRT and Blood
 Kidney Antibodies  >4 publications with QPRT and Kidney
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