NP_055113
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32.9 kDa (317aa), confirmed by MALDI-TOF
NCBI Official Full Name
nicotinate-nucleotide pyrophosphorylase
NCBI Official Synonym Full Names
quinolinate phosphoribosyltransferase
NCBI Protein Information
nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Protein Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Synonym Protein Names
Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
UniProt Synonym Gene Names
NCBI Summary for QPRT
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for QPRT
Involved in the catabolism of quinolinic acid (QA).
Product References and Citations for QPRT recombinant protein
Delaney J., et al. (2005) Arch Toxicol. 79 (2):208-223.; Eads J C., et al. (1997) Structure. 5:47-58.;
Research Articles on QPRT
Precautions
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Disclaimer
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Pathways associated with QPRT recombinant protein
Diseases associated with QPRT recombinant protein
Organs/Tissues associated with QPRT recombinant protein
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