NP_078914
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49.1kDa (438aa) confirmed by MALDI-TOF
NCBI Official Full Name
queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1
NCBI Official Synonym Full Names
queuine tRNA-ribosyltransferase accessory subunit 2
NCBI Official Synonym Symbols
NCBI Protein Information
queuine tRNA-ribosyltransferase accessory subunit 2; queuine tRNA-ribosyltransferase subunit QTRTD1
UniProt Protein Name
Queuine tRNA-ribosyltransferase accessory subunit 2
UniProt Synonym Protein Names
Queuine tRNA-ribosyltransferase domain-containing protein 1
NCBI Summary for QTRTD1
This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for QTRTD1
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Research Articles on QTRTD1
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Pathways associated with QTRTD1 recombinant protein
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