NP_001193731.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,402 Da
NCBI Official Full Name
quinone oxidoreductase PIG3 isoform 2
NCBI Official Synonym Full Names
tumor protein p53 inducible protein 3
NCBI Official Synonym Symbols
NCBI Protein Information
quinone oxidoreductase PIG3
UniProt Protein Name
Quinone oxidoreductase PIG3
UniProt Synonym Protein Names
Tumor protein p53-inducible protein 3; p53-induced gene 3 protein
UniProt Synonym Gene Names
NCBI Summary for TP53I3
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
UniProt Comments for TP53I3
May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).
Research Articles on TP53I3
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Products associated with TP53I3 recombinant protein
Pathways associated with TP53I3 recombinant protein
Diseases associated with TP53I3 recombinant protein
Organs/Tissues associated with TP53I3 recombinant protein
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