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RSPO1 recombinant protein :: R-spondin-1 (RSPO1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1449234 RSPO1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $645 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $865 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $935 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $955 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,055 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,170 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,175 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,195 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,695 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,780 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,810 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,260 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R-spondin-1 (RSPO1), Recombinant Protein

 Also Known As   

Recombinant Human R-spondin-1 (RSPO1)

 Product Gene Name   

RSPO1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    RSPO1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    21-263aa, Full Length of Mature Protein
 Sequence    SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA
 OMIM    609595
 3D Structure    ModBase 3D Structure for Q2MKA7
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RSPO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RSPO1 recombinant protein

   This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
NCBI/Uniprot data below describe general gene information for RSPO1. It may not necessarily be applicable to this product.
 NCBI GI #    84490388
 NCBI GeneID    284654
 NCBI Accession #    NP_001033722.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001038633.3 [Other Products]
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 UniProt Primary Accession #    Q2MKA7 [Other Products]
 UniProt Secondary Accession #    Q0H8S6; Q14C72; Q5T0F2; Q8N7L5; A2A420 [Other Products]
 UniProt Related Accession #    Q2MKA7 [Other Products]
 Molecular Weight    21,775 Da
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 NCBI Official Full Name    R-spondin-1 isoform 1
 NCBI Official Synonym Full Names    R-spondin 1
 NCBI Official Symbol    RSPO1 [Similar Products]
 NCBI Official Synonym Symbols   
RSPO; CRISTIN3
[Similar Products]
 NCBI Protein Information    R-spondin-1
 UniProt Protein Name    R-spondin-1
 UniProt Synonym Protein Names   
Roof plate-specific spondin-1; hRspo1
 Protein Family    R-spondin
 UniProt Gene Name    RSPO1 [Similar Products]
 UniProt Synonym Gene Names    hRspo1 [Similar Products]
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 NCBI Summary for RSPO1    This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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 UniProt Comments for RSPO1    Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).
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 Research Articles on RSPO1    1. Results showed that Rspo1 expression is downregulated in adult follicles but its activation is sufficient in promoting ovarian tumors supporting its direct involvement in the initiation of ovarian cancers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RSPO1 recombinant proteinPathways associated with RSPO1 recombinant protein
 Reference Product  PubMed Publications
 SRY recombinant protein  >33 publications with RSPO1 and SRY
 SOX9 recombinant protein  >29 publications with RSPO1 and SOX9
 FOXL2 recombinant protein  >19 publications with RSPO1 and FOXL2
 LRP6 recombinant protein  >11 publications with RSPO1 and LRP6
 DKK1 recombinant protein  >9 publications with RSPO1 and DKK1
 ZNRF3 recombinant protein  >7 publications with RSPO1 and ZNRF3
 FURIN recombinant protein  >7 publications with RSPO1 and FURIN
 STRA8 recombinant protein  >2 publications with RSPO1 and STRA8
 MYF5 recombinant protein  >1 publications with RSPO1 and MYF5
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Regulation Of FZD By Ubiquitination Pathway antibodies  Regulation Of FZD By Ubiquitination Pathway Diagram
Diseases associated with RSPO1 recombinant proteinOrgans/Tissues associated with RSPO1 recombinant protein
 Disease Name  Pubmed Publications
 Urogenital Abnormalities Antibodies  >23 publications with RSPO1 and Urogenital Abnormalities
 Neoplasms Antibodies  >12 publications with RSPO1 and Neoplasms
 Skin Diseases Antibodies  >5 publications with RSPO1 and Skin Diseases
 Embryo Loss Antibodies  >3 publications with RSPO1 and Embryo Loss
 Musculoskeletal Abnormalities Antibodies  >2 publications with RSPO1 and Musculoskeletal Abnormalities
 Adenocarcinoma Antibodies  >2 publications with RSPO1 and Adenocarcinoma
 Weight Loss Antibodies  >2 publications with RSPO1 and Weight Loss
 Hyperplasia Antibodies  >2 publications with RSPO1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >2 publications with RSPO1 and Neoplasms, Experimental
 Necrosis Antibodies  >2 publications with RSPO1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >32 publications with RSPO1 and Testis
 Ovary Antibodies  >31 publications with RSPO1 and Ovary
 Intestine Antibodies  >14 publications with RSPO1 and Intestine
 Pancreas Antibodies  >4 publications with RSPO1 and Pancreas
 Muscle Antibodies  >2 publications with RSPO1 and Muscle
 Connective Tissue Antibodies  >2 publications with RSPO1 and Connective Tissue
 Brain Antibodies  >2 publications with RSPO1 and Brain
 Eye Antibodies  >2 publications with RSPO1 and Eye
 Heart Antibodies  >1 publications with RSPO1 and Heart
 Prostate Antibodies  >1 publications with RSPO1 and Prostate
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