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IGF1 recombinant protein :: R3 IGF-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS845116 IGF1 recombinant protein
Unit / Price
0.1 mg  /  $160 +1 FREE 8GB USB
1 mg  /  $285 +1 FREE 8GB USB
5 mg  /  $805 +1 FREE 8GB USB
20 mg  /  $1,965 +2 FREE 8GB USB
50 mg  /  $3,315 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R3 IGF-1 (IGF1), Recombinant Protein

 Also Known As   

R3 IGF-1, human recombinant

 Product Synonym Names    Insulin-like Growth Factor-I; Somatamedin C; IGF-IA; Mechano growth factor
 Product Gene Name   

IGF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147440
 3D Structure    ModBase 3D Structure for P01343
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 Host    E Coli
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 Purity/Purification    >=97%
 Form/Format    Lyophilized with no additives
Appearance: Lyophilized protein
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 Solubility/Reconstitution Instructions    Reconstitute in dH?O or 10 mM AcOH to 1.0 mg/ml. This solution can then be diluted into other buffered solutions or stored at 4 degree C for 1 week or -20 degree C for future use.
 Endotoxin Level    <0.1 ng/mug
 Biological Activity    The ED?? as determined by a cell proliferation assay using NIH3T3 cells is typically 1-6 ng/ml.
 Results    1-6 ng/ml.
 Handling    Centrifuge the vial prior to opening.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of IGF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IGF1 recombinant protein

   Background: IGF-I (insulin-like Growth Factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. MyBioSource's recombinant human IGF-I is a N-terminus modified IGF-I with a Long R3 chain, which shows higher potency than regular human IGF-I in bioactivity assay. The recombinant IGF-I Long R3 was produced from E. coli using Animal Origin Free (AOF) components and therefore it is suitable for bioproduction also. The product can be provided as lyophilized form or liquid form, stable for at least two years.
 Product Categories/Family for IGF1 recombinant protein    Cytokines, Growth Factors & Hormones; R3 IGF1Cytokines, Growth Factors & Hormones; IGFsCytokines, Growth Factors & Hormones; Cytokines & Growth Factors (A-Z)Proteins and Enzymes; Cytokines, Growth Factors & Hormones; R3 IGF1 (NEW)Proteins and Enzymes; Cyt
 Applications Tested/Suitable for IGF1 recombinant protein   

SDS-PAGE; HPLC

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NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
 NCBI GI #    11024682
 NCBI GeneID    3479
 NCBI Accession #    NP_000609.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000618.3 [Other Products]
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 UniProt Primary Accession #    P01343 [Other Products]
 UniProt Secondary Accession #    P01343; Q14620; B2RWM7; E9PD02 [Other Products]
 UniProt Related Accession #    P05019 [Other Products]
 Molecular Weight    9.11 kDa
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 NCBI Official Full Name    insulin-like growth factor I isoform 4 preproprotein
 NCBI Official Synonym Full Names    insulin-like growth factor 1 (somatomedin C)
 NCBI Official Symbol    IGF1 [Similar Products]
 NCBI Official Synonym Symbols   
IGFI; IGF-I; IGF1A
[Similar Products]
 NCBI Protein Information    insulin-like growth factor I
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
Mechano growth factor; MGF; Somatomedin-C
 Protein Family    Insulin-like growth factor
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IBP1; IGF-I; MGF [Similar Products]
 UniProt Entry Name    IGF1_HUMAN
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 NCBI Summary for IGF1    The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
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 UniProt Comments for IGF1    IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; plasma membrane; extracellular region

Molecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding

Biological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; glycolate metabolic process; exocrine pancreas development; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of mitosis; positive regulation of protein import into nucleus, translocation; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; insulin-like growth factor receptor signaling pathway; response to heat; regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; myoblast proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of glycogen biosynthetic process; signal transduction; positive regulation of activated T cell proliferation; positive regulation of smooth muscle cell migration; negative regulation of cell proliferation; glial cell differentiation; platelet degranulation; positive regulation of MAPKKK cascade; mammary gland development; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; myotube cell development; regulation of multicellular organism growth; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of glycolysis; Ras protein signal transduction; blood vessel remodeling; positive regulation of Ras protein signal transduction; cell motility; blood coagulation; positive regulation of DNA replication

Disease: Insulin-like Growth Factor I Deficiency
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 Research Articles on IGF1    1. Results show that IGF1 may not have a significant role in the biochemical and clinical outcome in acromegaly. The role of IGF1 polymorphism in acromegaly susceptibility needs further investigation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF1 recombinant proteinPathways associated with IGF1 recombinant protein
 Reference Product  PubMed Publications
 IGF1R recombinant protein  >476 publications with IGF1 and IGF1R
 IGFBP3 recombinant protein  >239 publications with IGF1 and IGFBP3
 IGFBP1 recombinant protein  >81 publications with IGF1 and IGFBP1
 IRS1 recombinant protein  >71 publications with IGF1 and IRS1
 IGFBP2 recombinant protein  >67 publications with IGF1 and IGFBP2
 INSR recombinant protein  >44 publications with IGF1 and INSR
 TGFB1 recombinant protein  >31 publications with IGF1 and TGFB1
 IGFBP5 recombinant protein  >31 publications with IGF1 and IGFBP5
 INS recombinant protein  >28 publications with IGF1 and INS
 IGFBP4 recombinant protein  >27 publications with IGF1 and IGFBP4
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with IGF1 recombinant proteinOrgans/Tissues associated with IGF1 recombinant protein
 Disease Name  Pubmed Publications
 Acromegaly Antibodies  >139 publications with IGF1 and Acromegaly
 Breast Neoplasms Antibodies  >117 publications with IGF1 and Breast Neoplasms
 Inflammation Antibodies  >94 publications with IGF1 and Inflammation
 Female Urogenital Diseases Antibodies  >90 publications with IGF1 and Female Urogenital Diseases
 Liver Diseases Antibodies  >72 publications with IGF1 and Liver Diseases
 Adenoma Antibodies  >68 publications with IGF1 and Adenoma
 Prostatic Neoplasms Antibodies  >57 publications with IGF1 and Prostatic Neoplasms
 Necrosis Antibodies  >50 publications with IGF1 and Necrosis
 Pituitary Neoplasms Antibodies  >48 publications with IGF1 and Pituitary Neoplasms
 Hypertension Antibodies  >41 publications with IGF1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >658 publications with IGF1 and Blood
 Muscle Antibodies  >312 publications with IGF1 and Muscle
 Liver Antibodies  >281 publications with IGF1 and Liver
 Bone Antibodies  >275 publications with IGF1 and Bone
 Brain Antibodies  >225 publications with IGF1 and Brain
 Vascular Antibodies  >123 publications with IGF1 and Vascular
 Ovary Antibodies  >113 publications with IGF1 and Ovary
 Heart Antibodies  >111 publications with IGF1 and Heart
 Connective Tissue Antibodies  >107 publications with IGF1 and Connective Tissue
 Lung Antibodies  >91 publications with IGF1 and Lung
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