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RAB27A recombinant protein

Scan QR to view Datasheet Catalog #    MBS203472
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAB27A, Recombinant Protein

 Also Known As   

RAB27A, 1-221aa, Human, His tag, E Coli

 Product Synonym Names    Ras-related protein Rab-27A; GS2; RAM; RAB27; Ras-related protein Rab-27A GTP-binding protein Ram; HsT18676.MGC117246; Rab-27; RAB27A; member RAS oncogene family; Ras-related protein Rab27A.
 Product Gene Name   

RAB27A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C
 OMIM    U38654 mRNA
 3D Structure    ModBase 3D Structure for P51159
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 20% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of RAB27A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RAB27A recombinant protein

   Ras-related protein Rab-27A, also known as RAB27A, belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Also, RAB27A regulates the cytotoxic granule exocytosis and affect T-lymphocyte and macrophage-activation. It is widely expressed with significant expression in pancreatic islets and pituitary tissue, and low expression in brain. Defects in RAB27A cause Griscelli syndrome type 2 (GS2). Recombinant human RAB27A, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for RAB27A recombinant protein    Cancer
 Applications Tested/Suitable for RAB27A recombinant protein   

SDS-PAGE

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 SDS-Page of RAB27A recombinant protein    RAB27A recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for RAB27A. It may not necessarily be applicable to this product.
 NCBI GI #    34485711
 NCBI GeneID    5873
 NCBI Accession #    NP_899059 [Other Products]
 NCBI GenBank Nucleotide #    NM_183236.2 [Other Products]
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 UniProt Primary Accession #    P51159 [Other Products]
 UniProt Secondary Accession #    O00195; Q6FI40; Q9UIR9; Q9Y5U3 [Other Products]
 UniProt Related Accession #    P51159 [Other Products]
 Molecular Weight    27 kDa (241aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    ras-related protein Rab-27A
 NCBI Official Synonym Full Names    RAB27A, member RAS oncogene family
 NCBI Official Symbol    RAB27A [Similar Products]
 NCBI Official Synonym Symbols   
GS2; RAM; RAB27; HsT18676
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-27A
 UniProt Protein Name    Ras-related protein Rab-27A
 UniProt Synonym Protein Names   
GTP-binding protein Ram
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB27A [Similar Products]
 UniProt Synonym Gene Names    RAB27; Rab-27 [Similar Products]
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 NCBI Summary for RAB27A    The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RAB27A    Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
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Product References and Citations for RAB27A recombinant protein

   Kuroda TS., et al. (2002) J Biol Chem. 277 (11):9212-8.; Barral DC., et al. (2002) J Clin Invest. 110:61-5.;
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 Research Articles on RAB27A    1. These results demonstrated that miR-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RAB27A recombinant proteinPathways associated with RAB27A recombinant protein
 Reference Product  PubMed Publications
 MYO5A recombinant protein  >68 publications with RAB27A and MYO5A
 MLPH recombinant protein  >62 publications with RAB27A and MLPH
 UNC13D recombinant protein  >36 publications with RAB27A and UNC13D
 MYRIP recombinant protein  >24 publications with RAB27A and MYRIP
 SYTL2 recombinant protein  >13 publications with RAB27A and SYTL2
 RPH3AL recombinant protein  >11 publications with RAB27A and RPH3AL
 SYTL1 recombinant protein  >7 publications with RAB27A and SYTL1
 EXPH5 recombinant protein  >3 publications with RAB27A and EXPH5
 INS recombinant protein  >2 publications with RAB27A and INS
 Products by Pathway  Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 RAB GEFs Exchange GTP For GDP On RABs Pathway antibodies  RAB GEFs Exchange GTP For GDP On RABs Pathway Diagram
Diseases associated with RAB27A recombinant proteinOrgans/Tissues associated with RAB27A recombinant protein
 Disease Name  Pubmed Publications
 Griscelli syndrome type 2 Antibodies  >31 publications with RAB27A and Griscelli syndrome type 2
 Inflammation Antibodies  >28 publications with RAB27A and Inflammation
 Neoplasms, Experimental Antibodies  >14 publications with RAB27A and Neoplasms, Experimental
 Neoplasm Invasiveness Antibodies  >12 publications with RAB27A and Neoplasm Invasiveness
 Necrosis Antibodies  >9 publications with RAB27A and Necrosis
 Lung Diseases Antibodies  >6 publications with RAB27A and Lung Diseases
 Breast Neoplasms Antibodies  >6 publications with RAB27A and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >4 publications with RAB27A and Cell Transformation, Neoplastic
 Abnormalities, Multiple Antibodies  >4 publications with RAB27A and Abnormalities, Multiple
 Lung Neoplasms Antibodies  >3 publications with RAB27A and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >139 publications with RAB27A and Blood
 Skin Antibodies  >51 publications with RAB27A and Skin
 Pancreas Antibodies  >43 publications with RAB27A and Pancreas
 Brain Antibodies  >37 publications with RAB27A and Brain
 Bone Antibodies  >30 publications with RAB27A and Bone
 Lung Antibodies  >30 publications with RAB27A and Lung
 Bone Marrow Antibodies  >28 publications with RAB27A and Bone Marrow
 Heart Antibodies  >25 publications with RAB27A and Heart
 Eye Antibodies  >24 publications with RAB27A and Eye
 Liver Antibodies  >14 publications with RAB27A and Liver
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