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RAB27B recombinant protein

Scan QR to view Datasheet Catalog #    MBS203863
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAB27B, Recombinant Protein

 Also Known As   

RAB27B, 1-218aa, Human, His tag, E Coli

 Product Synonym Names    Ras-related protein Rab-27B; C25KG
 Product Gene Name   

RAB27B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR VVYNAQGPNG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLPDQ REVNERQARE LADKYGIPYF ETSAATGQNV EKAVETLLDL IMKRMEQCVE KTQIPDTVNG GNSGNLDGEK PPEKKCIC
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M Nacl, 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of RAB27B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for RAB27B recombinant protein

   RAB27B belongs to the RAB family and is a critical regulator of vesicular transport. This protein is expressed in pituitary tissue, but is more significantly expressed in brain and spleen. RAB27B may be functionally redundant to Rab27a, as it can rescue Rab27a mutants. Recombinant human RAB27B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for RAB27B recombinant protein    Signal Transduction
 Applications Tested/Suitable for RAB27B recombinant protein   

SDS-PAGE

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 SDS-PAGE of RAB27B recombinant protein    RAB27B recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for RAB27B. It may not necessarily be applicable to this product.
 NCBI GI #    5729997
 NCBI GeneID    5874
 NCBI Accession #    NP_004154 [Other Products]
 NCBI GenBank Nucleotide #    NM_004163.4 [Other Products]
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 UniProt Secondary Accession #    Q9BZB6; B2RAB0 [Other Products]
 UniProt Related Accession #    O00194 [Other Products]
 Molecular Weight    26.7 kDa (238aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    ras-related protein Rab-27B
 NCBI Official Synonym Full Names    RAB27B, member RAS oncogene family
 NCBI Official Symbol    RAB27B [Similar Products]
 NCBI Official Synonym Symbols   
C25KG
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-27B
 UniProt Protein Name    Ras-related protein Rab-27B
 UniProt Synonym Protein Names   
C25KG
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB27B [Similar Products]
 UniProt Entry Name    RB27B_HUMAN
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 NCBI Summary for RAB27B    Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]
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 UniProt Comments for RAB27B    RAB27B: May be involved in targeting uroplakins to urothelial apical membranes. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 18q21.2

Cellular Component: trans-Golgi network transport vesicle; Golgi stack; zymogen granule membrane; apical plasma membrane; melanosome; secretory granule

Molecular Function: GTPase activity; protein domain specific binding; protein binding; GDP binding; GTP binding; myosin V binding

Biological Process: intracellular protein transport; metabolic process; protein secretion; Rab protein signal transduction; melanosome transport; vesicle docking during exocytosis; positive regulation of exocytosis
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Product References and Citations for RAB27B recombinant protein

   Ostrowski M., et al. (2010) Nat Cell Biol. 12(1):19-30.
Song J., et al. (2009) Proc Natl Acad Sci u S A. 106(35):14966-71.
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 Research Articles on RAB27B    1. Silencing of the exocytotic RAB family members RAB27A or RAB27B halted miR23b and miR921 secretion and reduced cellular invasion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RAB27B recombinant proteinPathways associated with RAB27B recombinant protein
 Reference Product  PubMed Publications
 SYTL4 recombinant protein  >7 publications with RAB27B and SYTL4
 MYO5A recombinant protein  >6 publications with RAB27B and MYO5A
 MLPH recombinant protein  >6 publications with RAB27B and MLPH
 MYRIP recombinant protein  >6 publications with RAB27B and MYRIP
 UNC13D recombinant protein  >4 publications with RAB27B and UNC13D
 SYTL2 recombinant protein  >3 publications with RAB27B and SYTL2
 SYTL1 recombinant protein  >1 publications with RAB27B and SYTL1
 Products by Pathway  Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
Diseases associated with RAB27B recombinant proteinOrgans/Tissues associated with RAB27B recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >7 publications with RAB27B and Carcinoma
 Neoplasms, Experimental Antibodies  >5 publications with RAB27B and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >5 publications with RAB27B and Breast Neoplasms
 Inflammation Antibodies  >5 publications with RAB27B and Inflammation
 Lung Neoplasms Antibodies  >3 publications with RAB27B and Lung Neoplasms
 Disease Models, Animal Antibodies  >3 publications with RAB27B and Disease Models, Animal
 Adenocarcinoma Antibodies  >2 publications with RAB27B and Adenocarcinoma
 Liver Diseases Antibodies  >2 publications with RAB27B and Liver Diseases
 Mammary Neoplasms, Experimental Antibodies  >2 publications with RAB27B and Mammary Neoplasms, Experimental
 Necrosis Antibodies  >2 publications with RAB27B and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with RAB27B and Blood
 Lung Antibodies  >11 publications with RAB27B and Lung
 Brain Antibodies  >9 publications with RAB27B and Brain
 Eye Antibodies  >6 publications with RAB27B and Eye
 Pancreas Antibodies  >6 publications with RAB27B and Pancreas
 Bone Antibodies  >6 publications with RAB27B and Bone
 Bone Marrow Antibodies  >5 publications with RAB27B and Bone Marrow
 Nerve Antibodies  >5 publications with RAB27B and Nerve
 Testis Antibodies  >3 publications with RAB27B and Testis
 Mouth Antibodies  >3 publications with RAB27B and Mouth
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