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RAB7A recombinant protein

Scan QR to view Datasheet Catalog #    MBS144887 RAB7A recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAB7A, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human RAB7A, Member RAS Oncogene Family

 Product Synonym Names    RAB7A Human; RAB7A, Member RAS Oncogene Family Human Recombinant; RAB7A member RAS oncogene family; RAB7; ras-related protein Rab-7a; FLJ20819; PSN; CMT2B; PRO2706
 Product Gene Name   

RAB7A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKA SAESCSC
 OMIM    600882
 3D Structure    ModBase 3D Structure for P51149
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The RAB7A protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT, 100mM NaCl and 30% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of RAB7A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RAB7A recombinant protein

   Description: RAB7A produced in E Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (1-207a.a.) and having a molecular mass of 25.6kDa.RAB7A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: RAB7A belongs to the Ras superfamily of small Rab GTPases. RAB7A connects with the RIPL effector protein to regulator membrane trafficking from early to late endosome and to lysosomes. RAB7A can also regulate growth receptor endocytic trafficking, degradation, maturation of phagosome and autophagic vacuoles.
 Product Categories/Family for RAB7A recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Member RAS Oncogene Family
NCBI/Uniprot data below describe general gene information for RAB7A. It may not necessarily be applicable to this product.
 NCBI GI #    34147513
 NCBI GeneID    7879
 NCBI Accession #    NP_004628.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_004637.5 [Other Products]
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 UniProt Primary Accession #    P51149 [Other Products]
 UniProt Secondary Accession #    Q9NWJ0; Q9UPB0; A8K3V6 [Other Products]
 UniProt Related Accession #    P51149 [Other Products]
 Molecular Weight    23,490 Da
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 NCBI Official Full Name    ras-related protein Rab-7a
 NCBI Official Synonym Full Names    RAB7A, member RAS oncogene family
 NCBI Official Symbol    RAB7A [Similar Products]
 NCBI Official Synonym Symbols   
RAB7; PRO2706
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-7a; RAB7, member RAS oncogene family; Ras-associated protein RAB7
 UniProt Protein Name    Ras-related protein Rab-7a
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB7A [Similar Products]
 UniProt Synonym Gene Names    RAB7 [Similar Products]
 UniProt Entry Name    RAB7A_HUMAN
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 NCBI Summary for RAB7A    RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RAB7A    Rab7: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy.

Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; lysosomal membrane; retromer complex; lysosome; pre-autophagosomal structure membrane; vacuolar membrane; late endosome; melanosome; phagocytic vesicle

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding

Biological Process: protein transport; protein targeting to lysosome; early endosome to late endosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; endosome to lysosome transport; protein to membrane docking; endocytosis; Rab protein signal transduction; retrograde transport, endosome to Golgi; epidermal growth factor ligand processing; bone resorption

Disease: Charcot-marie-tooth Disease, Axonal, Type 2b
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 Research Articles on RAB7A    1. LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RAB7A recombinant proteinPathways associated with RAB7A recombinant protein
 Reference Product  PubMed Publications
 RAB5A recombinant protein  >6 publications with RAB7A and RAB5A
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
Diseases associated with RAB7A recombinant proteinOrgans/Tissues associated with RAB7A recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with RAB7A and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >2 publications with RAB7A and Peripheral Nervous System Diseases
 Charcot-Marie-Tooth disease, Type 2B Antibodies  >2 publications with RAB7A and Charcot-Marie-Tooth disease, Type 2B
 Fever Antibodies  >1 publications with RAB7A and Fever
 Liver Diseases Antibodies  >1 publications with RAB7A and Liver Diseases
 Inflammation Antibodies  >1 publications with RAB7A and Inflammation
 Kidney Diseases Antibodies  >1 publications with RAB7A and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with RAB7A and Liver
 Heart Antibodies  >3 publications with RAB7A and Heart
 Muscle Antibodies  >3 publications with RAB7A and Muscle
 Vascular Antibodies  >2 publications with RAB7A and Vascular
 Kidney Antibodies  >2 publications with RAB7A and Kidney
 Nerve Antibodies  >2 publications with RAB7A and Nerve
 Spleen Antibodies  >1 publications with RAB7A and Spleen
 Ganglia Antibodies  >1 publications with RAB7A and Ganglia
 Blood Antibodies  >1 publications with RAB7A and Blood
 Embryonic Tissue Antibodies  >1 publications with RAB7A and Embryonic Tissue
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