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RAC2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203164
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAC2, Recombinant Protein

 Also Known As   

RAC2, 1-192aa, Human, GST tag, Recombinant, E Coli

 Product Synonym Names    HSPC022; ras-related C3 botulinum toxin substrate 2; RAC2; EN-7; Gx; Ras-related C3 botulinum toxin substrate 2 EN 7; EN7; HSPC 022; p21 Rac 2; p21 Rac2; p21Rac2; RAC 2; Ras related C3 botulinum toxin substrate 2; Ras related C3 botulinum toxin substrate 3; Rho family small GTP binding protein Rac 2; Rho family small GTP binding protein Rac2; Small G protein.
 Product Gene Name   

RAC2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHMQA IKCVVVGDGA VGKTCLLISY TTNAFPGEYI PTVFDNYSAN VMVDSKPVNL GLWDTAGQED YDRLRPLSYP QTDVFLICFS LVSPASYENV RAKWFPEVRH HCPSTPIILV GTKLDLRDDK DTIEKLKEKK LAPITYPQGL ALAKEIDSVK YLECSALTQR GLKTVFDEAI RAVLCPQPTR QQKRACSLL
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid in Phosphate Buffered Saline pH 7.4
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    GST tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of RAC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for RAC2 recombinant protein

   Rac2 is a small signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Rac proteins play important roles in multiple cellular events, including actin cytoskeletal organization, cell proliferation and survival, cell cycle progression, and gene transcription regulation. Recombinant GST tagged RAC2 was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for RAC2 recombinant protein    Signal Transduction
 Applications Tested/Suitable for RAC2 recombinant protein   

SDS-PAGE

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 SDS-PAGE of RAC2 recombinant protein    RAC2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for RAC2. It may not necessarily be applicable to this product.
 NCBI GI #    4506381
 NCBI GeneID    5880
 NCBI Accession #    NP_002863 [Other Products]
 NCBI GenBank Nucleotide #    NM_002872.4 [Other Products]
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 UniProt Secondary Accession #    Q9UDJ4 [Other Products]
 UniProt Related Accession #    P15153; AAB22207 [Other Products]
 Molecular Weight    47 kDa (419 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    ras-related C3 botulinum toxin substrate 2
 NCBI Official Synonym Full Names    ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
 NCBI Official Symbol    RAC2 [Similar Products]
 NCBI Official Synonym Symbols   
Gx; EN-7; HSPC022; p21-Rac2
[Similar Products]
 NCBI Protein Information    ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); small G protein
 UniProt Protein Name    Ras-related C3 botulinum toxin substrate 2
 UniProt Synonym Protein Names   
GX; Small G protein; p21-Rac2
 Protein Family    Ras-related protein
 UniProt Gene Name    RAC2 [Similar Products]
 UniProt Entry Name    RAC2_HUMAN
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 NCBI Summary for RAC2    This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
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 UniProt Comments for RAC2    RAC2: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: focal adhesion; lamellipodium; plasma membrane; nuclear envelope; actin filament; cytosol

Molecular Function: GTPase activity; GTP binding

Biological Process: platelet activation; axon guidance; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; metabolic process; small GTPase mediated signal transduction; positive regulation of cell proliferation; actin filament organization; cell projection biogenesis; blood coagulation; signal transduction; regulation of hydrogen peroxide metabolic process; bone resorption

Disease: Neutrophil Immunodeficiency Syndrome
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Product References and Citations for RAC2 recombinant protein

   Yi Gu., et al. (2002). Mol Cell Biol. 22(21):7645-57.
Tarricone C., et al. (2001). Nature. 411(6834):215-9.
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 Research Articles on RAC2    1. p47(phox) and Rac2 accumulate only transiently at the phagosome at the onset of NADPH activity and detach from the phagosome before the end of reactive oxygen species production.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RAC2 recombinant proteinPathways associated with RAC2 recombinant protein
 Reference Product  PubMed Publications
 VAV1 recombinant protein  >22 publications with RAC2 and VAV1
 NCF2 recombinant protein  >4 publications with RAC2 and NCF2
 ARHGDIB recombinant protein  >4 publications with RAC2 and ARHGDIB
 PAK2 recombinant protein  >2 publications with RAC2 and PAK2
 ARHGDIA recombinant protein  >2 publications with RAC2 and ARHGDIA
 RACGAP1 recombinant protein  >1 publications with RAC2 and RACGAP1
 Products by Pathway  Pathway Diagram
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 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
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Diseases associated with RAC2 recombinant proteinOrgans/Tissues associated with RAC2 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >50 publications with RAC2 and Inflammation
 Neutrophil Immunodeficiency Syndrome Antibodies  >17 publications with RAC2 and Neutrophil Immunodeficiency Syndrome
 Disease Models, Animal Antibodies  >15 publications with RAC2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >13 publications with RAC2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >12 publications with RAC2 and Nervous System Diseases
 Necrosis Antibodies  >10 publications with RAC2 and Necrosis
 Lymphoma Antibodies  >10 publications with RAC2 and Lymphoma
 Neoplasm Metastasis Antibodies  >8 publications with RAC2 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >6 publications with RAC2 and Neoplasms, Experimental
 Anemia Antibodies  >6 publications with RAC2 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >270 publications with RAC2 and Blood
 Bone Antibodies  >77 publications with RAC2 and Bone
 Bone Marrow Antibodies  >67 publications with RAC2 and Bone Marrow
 Vascular Antibodies  >23 publications with RAC2 and Vascular
 Lung Antibodies  >16 publications with RAC2 and Lung
 Brain Antibodies  >15 publications with RAC2 and Brain
 Eye Antibodies  >11 publications with RAC2 and Eye
 Liver Antibodies  >10 publications with RAC2 and Liver
 Spleen Antibodies  >10 publications with RAC2 and Spleen
 Heart Antibodies  >8 publications with RAC2 and Heart
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