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RALB recombinant protein

Scan QR to view Datasheet Catalog #    MBS203935
SDS-Page
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RALB, Recombinant Protein

 Also Known As   

RALB, 1-203aa, Human, His tag, E Coli

 Product Synonym Names    Ras-related protein Ral-B
 Product Gene Name   

RALB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMAANKS KGQSSLALHK VIMVGSGGVG KSALTLQFMY DEFVEDYEPT KADSYRKKVV LDGEEVQIDI LDTAGQEDYA AIRDNYFRSG EGFLLVFSIT EHESFTATAE FREQILRVKA EEDKIPLLVV GNKSDLEERR QVPVEEARSK AEEWGVQYVE TSAKTRANVD KVFFDLMREI RTKKMSENKD KNGKKSSKNK KSFKERC
 OMIM    X15015 mRNA
 3D Structure    ModBase 3D Structure for P11234
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl, 1mM DTT
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of RALB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RALB recombinant protein

   RALB, also called Ras-related protein Ral-B, belongs to subfamily of Ras-related GTPases. This protein is activated by a unique nucleotide exchange factor, Ral GDS, and deactivated by a distinct GTPase-activating protein. It plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Also it is required for suppression of apoptosis. Recombinant human RALB protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for RALB recombinant protein    Signal Transduction
 Applications Tested/Suitable for RALB recombinant protein   

SDS-PAGE

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 SDS-Page of RALB recombinant protein    RALB recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for RALB. It may not necessarily be applicable to this product.
 NCBI GI #    4506405
 NCBI GeneID    5899
 NCBI Accession #    NP_002872 [Other Products]
 NCBI GenBank Nucleotide #    NM_002881.2 [Other Products]
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 UniProt Primary Accession #    P11234 [Other Products]
 UniProt Secondary Accession #    Q53T32; Q6ZS74; B4E040 [Other Products]
 UniProt Related Accession #    P11234 [Other Products]
 Molecular Weight    25.6 kDa (227aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    ras-related protein Ral-B
 NCBI Official Synonym Full Names    RAS like proto-oncogene B
 NCBI Official Symbol    RALB [Similar Products]
 NCBI Protein Information    ras-related protein Ral-B
 UniProt Protein Name    Ras-related protein Ral-B
 Protein Family    Ras-related protein
 UniProt Gene Name    RALB [Similar Products]
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 NCBI Summary for RALB    This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RALB    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
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Product References and Citations for RALB recombinant protein

   Wildey G.M., et al. (1993), Biochem. Biophys. Res. Comm., 194: 552-559.; Jullien-Flores V., et al. (1995). J. Biol. Chem. 270: 22473-22477
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 Research Articles on RALB    1. This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RALB recombinant proteinPathways associated with RALB recombinant protein
 Reference Product  PubMed Publications
 RALGDS recombinant protein  >29 publications with RALB and RALGDS
 RALBP1 recombinant protein  >26 publications with RALB and RALBP1
 EXOC2 recombinant protein  >9 publications with RALB and EXOC2
 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 EGF/EGFR Signaling Pathway antibodies  EGF/EGFR Signaling Pathway Diagram
 NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies  NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram
 Pancreatic Cancer Pathway antibodies  Pancreatic Cancer Pathway Diagram
 Pancreatic Cancer Pathway antibodies  Pancreatic Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Phospholipase D Signaling Pathway antibodies  Phospholipase D Signaling Pathway Diagram
 Phospholipase D Signaling Pathway antibodies  Phospholipase D Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
Diseases associated with RALB recombinant proteinOrgans/Tissues associated with RALB recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >28 publications with RALB and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >21 publications with RALB and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >17 publications with RALB and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >13 publications with RALB and Pancreatic Neoplasms
 Adenocarcinoma Antibodies  >9 publications with RALB and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >8 publications with RALB and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >6 publications with RALB and Neoplasms, Experimental
 Liver Diseases Antibodies  >4 publications with RALB and Liver Diseases
 Inflammation Antibodies  >4 publications with RALB and Inflammation
 Carcinoma, Squamous Cell Antibodies  >4 publications with RALB and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >20 publications with RALB and Lung
 Blood Antibodies  >19 publications with RALB and Blood
 Brain Antibodies  >15 publications with RALB and Brain
 Bladder Antibodies  >10 publications with RALB and Bladder
 Kidney Antibodies  >9 publications with RALB and Kidney
 Muscle Antibodies  >9 publications with RALB and Muscle
 Prostate Antibodies  >6 publications with RALB and Prostate
 Embryonic Tissue Antibodies  >5 publications with RALB and Embryonic Tissue
 Liver Antibodies  >5 publications with RALB and Liver
 Skin Antibodies  >4 publications with RALB and Skin
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