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RANKL recombinant protein :: RANKL, soluble Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS691818 RANKL recombinant protein
Unit / Price
0.002 mg  /  $215 +1 FREE 8GB USB
0.01 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RANKL, soluble, Recombinant Protein

★Popular Item★
 Also Known As   

Rat RANKL, soluble

 Product Synonym Names    Soluble Receptor Activator of NFkB Ligand; TNFSF11; TRANCE (TNF-related activation-induced cytokine); OPGL; ODF (Osteoclast differentiation factor)
 Product Gene Name   

RANKL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    PAMMEGSWLD VARRGKPEAQ PFAHLTINAA DIPSGSHKVS LSSWYH DRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPA D YLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGF FKL RAGEEISVQV SNPSLLDPDQ DATYFGAFKV QDID
 Chromosome Location    Chromosome: 15; NC_005114.3 (64155680..64186116, complement). Location: 15q11
 3D Structure    ModBase 3D Structure for Q9ESE2
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 Host    E Coli
 Species Reactivity    Rat
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 Purity/Purification    > 98% by SDS-PAGE & HPLC analyses
 Form/Format    Lyophilized
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 Endotoxin level    <0.1 ng /ug of protein (<1EU/ug)
 Reconsitution    Centrifuge the vial prior to opening.Reconstitute in water to a concentration of 0.1-1.0 mg/m. do not vertex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
 Biological Activity    Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 10.0-25.0 ng/ml.
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 Preparation and Storage    Stability: The lyophilized protein is stable at room temperature for 1 month and at 4 degree C for 6 months. Reconstituted working aliquots are stable for 1 week at 2 degree C to 8 degree C and for 3 months at -20 degree C to -80 degree C.
Avoid freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of RANKL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RANKL recombinant protein

   RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant rat sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).
 Product Categories/Family for RANKL recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for RANKL. It may not necessarily be applicable to this product.
 NCBI GI #    16924012
 NCBI GeneID    117516
 NCBI Accession #    NP_476490.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_057149.1 [Other Products]
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 UniProt Primary Accession #    Q9ESE2 [Other Products]
 UniProt Secondary Accession #    Q91ZI9 [Other Products]
 UniProt Related Accession #    Q9ESE2 [Other Products]
 Molecular Weight    19.4kDa
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 11
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 11
 NCBI Official Symbol    Tnfsf11 [Similar Products]
 NCBI Official Synonym Symbols   
RANKL
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11; ODF; OPGL; TRANCE; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine
 UniProt Gene Name    Tnfsf11 [Similar Products]
 UniProt Synonym Gene Names    Opgl; Rankl; Trance; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_RAT
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 NCBI Summary for RANKL    induces osteoclast formation and bone resoprtion; plays a role in regulation of calcium homeostasis and osteoclast function [RGD, Feb 2006]
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 UniProt Comments for RANKL    Function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subunit structure: Homotrimer. Interacts with TNFRSF11A and TNFRSF11B

By similarity.

Subcellular location: Cell membrane; Single-pass type II membrane protein

By similarity. Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted

By similarity.

Tissue specificity: Highly expressed in thymus and bone tissues.

Post-translational modification: The soluble form derives from the membrane form by proteolytic processing

By similarity.

Sequence similarities: Belongs to the tumor necrosis factor family.
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 Research Articles on RANKL    1. Our findings indicate that the expression of RANKL in the occlusal portion of the bony crypt is unrelated to osteoclast recruitment and differentiation but is crucial to their activation during the creation of the eruption pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RANKL recombinant proteinDiseases associated with RANKL recombinant protein
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoblast Pathway antibodies  Osteoblast Pathway Diagram
 Osteoclast Pathway antibodies  Osteoclast Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1483 publications with RANKL and Necrosis
 Osteoporosis Antibodies  >1028 publications with RANKL and Osteoporosis
 Neoplasms Antibodies  >867 publications with RANKL and Neoplasms
 Inflammation Antibodies  >475 publications with RANKL and Inflammation
 Osteolysis Antibodies  >325 publications with RANKL and Osteolysis
 Cardiovascular Diseases Antibodies  >289 publications with RANKL and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >213 publications with RANKL and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >146 publications with RANKL and Prostatic Neoplasms
 Alveolar Bone Loss Antibodies  >136 publications with RANKL and Alveolar Bone Loss
 Osteopetrosis Antibodies  >118 publications with RANKL and Osteopetrosis
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