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RANKL recombinant protein

Scan QR to view Datasheet Catalog #    MBS286161 RANKL recombinant protein
Unit / Price
0.1 mg  /  $380 +1 FREE 8GB USB
0.5 mg  /  $1,065 +1 FREE 8GB USB
1 mg  /  $1,485 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RANKL, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human RANKL Protein

 Product Synonym Names    OPGL;  RANKL;  TRANCE; TNFSF11
 Product Gene Name   

RANKL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF019047 mRNA
 3D Structure    ModBase 3D Structure for O14788
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 Host    Yeast
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 Purity/Purification    > 90 % as determined by SDS-PAGE
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 Other Notes    Small volumes of RANKL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for RANKL recombinant protein   

Western Blot (WB), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for RANKL. It may not necessarily be applicable to this product.
 NCBI GI #    4507595
 NCBI GeneID    8600
 NCBI Accession #    NP_003692.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003701.3 [Other Products]
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 UniProt Primary Accession #    O14788 [Other Products]
 UniProt Secondary Accession #    O14723; Q96Q17; Q9P2Q3 [Other Products]
 UniProt Related Accession #    O14788 [Other Products]
 Molecular Weight    20 kDa
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 11 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor superfamily member 11
 NCBI Official Symbol    TNFSF11 [Similar Products]
 NCBI Official Synonym Symbols   
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF
 UniProt Gene Name    TNFSF11 [Similar Products]
 UniProt Synonym Gene Names    OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_HUMAN
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 NCBI Summary for RANKL    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RANKL    TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: extracellular region; plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding

Biological Process: activation of NF-kappaB transcription factor; calcium-mediated signaling; cytokine and chemokine mediated signaling pathway; monocyte chemotaxis; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway

Disease: Osteopetrosis, Autosomal Recessive 2
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 Research Articles on RANKL    1. Results showed that the expressions of RANKL and IL-17A were higher in the treatment group than the nontreatment group (P < .05) and higher in males than in females (P < .05). Their increments were well correlated with each other (r = 0.788, P = < .01) but were not time dependent
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RANKL recombinant proteinPathways associated with RANKL recombinant protein
 Reference Product  PubMed Publications
 TNFRSF11A recombinant protein  >1513 publications with RANKL and TNFRSF11A
 TNFRSF11B recombinant protein  >922 publications with RANKL and TNFRSF11B
 FOS recombinant protein  >132 publications with RANKL and FOS
 PTH recombinant protein  >127 publications with RANKL and PTH
 CTSK recombinant protein  >100 publications with RANKL and CTSK
 TRAF6 recombinant protein  >90 publications with RANKL and TRAF6
 SRC recombinant protein  >66 publications with RANKL and SRC
 SOST recombinant protein  >36 publications with RANKL and SOST
 STAT3 recombinant protein  >25 publications with RANKL and STAT3
 PTHLH recombinant protein  >7 publications with RANKL and PTHLH
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 Immune System Pathway antibodies  Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
Diseases associated with RANKL recombinant proteinOrgans/Tissues associated with RANKL recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1071 publications with RANKL and Necrosis
 Osteoporosis Antibodies  >512 publications with RANKL and Osteoporosis
 Inflammation Antibodies  >279 publications with RANKL and Inflammation
 Osteolysis Antibodies  >207 publications with RANKL and Osteolysis
 Cardiovascular Diseases Antibodies  >174 publications with RANKL and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >98 publications with RANKL and Breast Neoplasms
 Osteopetrosis Antibodies  >87 publications with RANKL and Osteopetrosis
 Alveolar Bone Loss Antibodies  >62 publications with RANKL and Alveolar Bone Loss
 Pain Antibodies  >47 publications with RANKL and Pain
 Neoplasms, Experimental Antibodies  >44 publications with RANKL and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >365 publications with RANKL and Connective Tissue
 Lymph Node Antibodies  >50 publications with RANKL and Lymph Node
 Liver Antibodies  >42 publications with RANKL and Liver
 Brain Antibodies  >34 publications with RANKL and Brain
 Pancreas Antibodies  >3 publications with RANKL and Pancreas
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