NP_001010935.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,987 Da
NCBI Official Full Name
ras-related protein Rap-1A
NCBI Official Synonym Full Names
RAP1A, member of RAS oncogene family
NCBI Official Synonym Symbols
RAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21 [Similar Products]
NCBI Protein Information
ras-related protein Rap-1A; GTP-binding protein smg p21A; Ras-related protein Krev-1
UniProt Protein Name
Ras-related protein Rap-1A
UniProt Synonym Protein Names
C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1
UniProt Synonym Gene Names
UniProt Entry Name
RAP1A_HUMAN
NCBI Summary for RAP1A
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for RAP1A
RAP1A: a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3.
Protein type: G protein, monomeric, Ras; G protein, monomeric; G protein; Tumor suppressor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: neuron projection; perinuclear region of cytoplasm; late endosome; early endosome; cytoplasm; plasma membrane; cytosol; cell junction
Molecular Function: GTPase activity; Rap guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding; GTP binding; protein complex binding; protein transporter activity
Biological Process: platelet activation; microvillus biogenesis; protein transport; activation of MAPKK activity; nerve growth factor receptor signaling pathway; positive regulation of protein kinase activity; energy reserve metabolic process; signal transduction; blood coagulation; regulation of insulin secretion; Rap protein signal transduction
Research Articles on RAP1A
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Products associated with RAP1A recombinant protein
Pathways associated with RAP1A recombinant protein
Diseases associated with RAP1A recombinant protein
Organs/Tissues associated with RAP1A recombinant protein
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