NP_001270872.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
40,162 Da
NCBI Official Full Name
RCC1 domain-containing protein 1
NCBI Protein Information
RCC1 domain-containing protein 1
UniProt Protein Name
RCC1 domain-containing protein 1
UniProt Comments for RCCD1
Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated 'Lys-36' (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.
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Diseases associated with RCCD1 recombinant protein
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