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Rest recombinant protein :: RE1-silencing transcription factor (Rest) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1120363 Rest recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RE1-silencing transcription factor (Rest), Recombinant Protein

 Also Known As   

Recombinant Rat RE1-silencing transcription factor (Rest) , partial

 Product Gene Name   

Rest recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O54963
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Rest recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Rest recombinant protein

   This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described; however, their full length nature has not been determined.
NCBI/Uniprot data below describe general gene information for Rest. It may not necessarily be applicable to this product.
 NCBI GI #    13929116
 NCBI GeneID    83618
 NCBI Accession #    NP_113976.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031788.1 [Other Products]
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 UniProt Primary Accession #    O54963 [Other Products]
 UniProt Secondary Accession #    O54964 [Other Products]
 UniProt Related Accession #    O54963 [Other Products]
 Molecular Weight    37,821 Da
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 NCBI Official Full Name    RE1-silencing transcription factor
 NCBI Official Synonym Full Names    RE1-silencing transcription factor
 NCBI Official Symbol    Rest [Similar Products]
 NCBI Official Synonym Symbols   
Nrsf
[Similar Products]
 NCBI Protein Information    RE1-silencing transcription factor
 UniProt Protein Name    RE1-silencing transcription factor
 UniProt Synonym Protein Names   
Neural-restrictive silencer factor
 Protein Family    RE1-silencing transcription factor
 UniProt Gene Name    Rest [Similar Products]
 UniProt Synonym Gene Names    Nrsf [Similar Products]
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 NCBI Summary for Rest    represses transcription of the AMPA receptor (AMPAR) subunit GluR2 and other neural genes [RGD, Feb 2006]
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 UniProt Comments for Rest    Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (PubMed:9454838). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression ().
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 Research Articles on Rest    1. Authors demonstrate for the first time novel neuroprotective function of REST in prion diseases and hypothesise that the LRP6-Wnt-beta-catenin/REST signaling plays critical and collaborative roles in neuroprotection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Rest recombinant proteinPathways associated with Rest recombinant protein
 Reference Product  PubMed Publications
 Stmn2 recombinant protein  >5 publications with Rest and Stmn2
 Chrm4 recombinant protein  >1 publications with Rest and Chrm4
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with Rest recombinant proteinOrgans/Tissues associated with Rest recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11961 publications with Rest and Nervous System Diseases
 Neoplasms Antibodies  >6797 publications with Rest and Neoplasms
 Hypertension Antibodies  >5424 publications with Rest and Hypertension
 Brain Diseases Antibodies  >4159 publications with Rest and Brain Diseases
 Myocardial Infarction Antibodies  >4029 publications with Rest and Myocardial Infarction
 Fatigue Antibodies  >2848 publications with Rest and Fatigue
 Carcinoma Antibodies  >2329 publications with Rest and Carcinoma
 Congenital Abnormalities Antibodies  >2142 publications with Rest and Congenital Abnormalities
 Drug Toxicity Antibodies  >1701 publications with Rest and Drug Toxicity
 Liver Diseases Antibodies  >1315 publications with Rest and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2178 publications with Rest and Kidney
 Embryonic Tissue Antibodies  >424 publications with Rest and Embryonic Tissue
 Pituitary Gland Antibodies  >209 publications with Rest and Pituitary Gland
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