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REN recombinant protein

Scan QR to view Datasheet Catalog #    MBS205451
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

REN, Recombinant Protein

★Popular Item★
 Also Known As   

REN, 67-406aa, Human, His tag, E Coli (Denatured)

 Product Synonym Names    Renin; HNFJ2
 Product Gene Name   

REN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMLTLGN TTSSVILTNY MDTQYYGEIG IGTPPQTFKV VFDTGSSNVW VPSSKCSRLY TACVYHKLFD ASDSSSYKHN GTELTLRYST GTVSGFLSQD IITVGGITVT QMFGEVTEMP ALPFMLAEFD GVVGMGFIEQ AIGRVTPIFD NIISQGVLKE DVFSFYYNRD SENSQSLGGQ IVLGGSDPQH YEGNFHYINL IKTGVWQIQM KGVSVGSSTL LCEDGCLALV DTGASYISGS TSSIEKLMEA LGAKKRLFDY VVKCNEGPTL PDISFHLGGK EYTLTSADYV FQESYSSKKL CTLAIHAMDI PPPTGPTWAL GATFIRKFYT EFDRRNNRIG FALAR
 OMIM    L00073
 3D Structure
   ModBase 3D Structure for P00797
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 Host    E Coli
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 Purity/Purification    > 80% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of REN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for REN recombinant protein

   Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. Recombinant human REN protein, fused to His-tag at N-terminus, was expressed in E Coli.
 Product Categories/Family for REN recombinant protein    Metabolism
 Applications Tested/Suitable for REN recombinant protein   

SDS-PAGE

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 SDS-Page of REN recombinant protein    REN recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
 NCBI GI #    4506475
 NCBI GeneID    5972
 NCBI Accession #    NP_000528 [Other Products]
 NCBI GenBank Nucleotide #    NM_000537.3 [Other Products]
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 UniProt Primary Accession #    P00797 [Other Products]
 UniProt Secondary Accession #    Q6FI38; Q6T5C2 [Other Products]
 UniProt Related Accession #    P00797 [Other Products]
 Molecular Weight    39.9kDa (365aa)
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 NCBI Official Full Name    renin preproprotein
 NCBI Official Synonym Full Names    renin
 NCBI Official Symbol    REN [Similar Products]
 NCBI Official Synonym Symbols   
HNFJ2
[Similar Products]
 NCBI Protein Information    renin
 UniProt Protein Name    Renin
 UniProt Synonym Protein Names   
Angiotensinogenase
 Protein Family    Renin
 UniProt Gene Name    REN [Similar Products]
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 NCBI Summary for REN    Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for REN    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
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Product References and Citations for REN recombinant protein

   Gribouval O., et al. (2005) Nat. Genet. 37:964-968; Zivna M., et al. (2009) Am. J. Hum. Genet. 85:204-213
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 Research Articles on REN    1. Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with REN recombinant proteinPathways associated with REN recombinant protein
 Reference Product  PubMed Publications
 ACE recombinant protein  >192 publications with REN and ACE
 AGT recombinant protein  >84 publications with REN and AGT
 INS recombinant protein  >52 publications with REN and INS
 AGTR2 recombinant protein  >36 publications with REN and AGTR2
 AGTR1 recombinant protein  >34 publications with REN and AGTR1
 ATP6AP2 recombinant protein  >10 publications with REN and ATP6AP2
 KNG1 recombinant protein  >4 publications with REN and KNG1
 PCSK5 recombinant protein  >1 publications with REN and PCSK5
 EDN1 recombinant protein  >1 publications with REN and EDN1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with REN recombinant proteinOrgans/Tissues associated with REN recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >5463 publications with REN and Kidney Diseases
 Renal Insufficiency Antibodies  >3609 publications with REN and Renal Insufficiency
 Heart Diseases Antibodies  >1667 publications with REN and Heart Diseases
 Hypertension Antibodies  >1647 publications with REN and Hypertension
 Necrosis Antibodies  >1372 publications with REN and Necrosis
 Acute Kidney Injury Antibodies  >1070 publications with REN and Acute Kidney Injury
 Ischemia Antibodies  >957 publications with REN and Ischemia
 Fibrosis Antibodies  >821 publications with REN and Fibrosis
 Myocardial Ischemia Antibodies  >779 publications with REN and Myocardial Ischemia
 Proteinuria Antibodies  >628 publications with REN and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6841 publications with REN and Kidney
 Lung Antibodies  >1953 publications with REN and Lung
 Skin Antibodies  >770 publications with REN and Skin
 Intestine Antibodies  >617 publications with REN and Intestine
 Embryonic Tissue Antibodies  >337 publications with REN and Embryonic Tissue
 Pancreas Antibodies  >270 publications with REN and Pancreas
 Bladder Antibodies  >228 publications with REN and Bladder
 Ovary Antibodies  >219 publications with REN and Ovary
 Testis Antibodies  >200 publications with REN and Testis
 Placenta Antibodies  >126 publications with REN and Placenta
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