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RQCD1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203971
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RQCD1, Recombinant Protein

 Also Known As   

RQCD1, 1-299aa, Human, His tag, E Coli

 Product Synonym Names    Cell differentiation protein RCD1 homolog; Cell differentiation protein RCD1 homolog; CNOT9; CT129; RCD1
 Product Gene Name   

RQCD1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ
 OMIM    D87957 Genomic DNA
 3D Structure    ModBase 3D Structure for Q92600
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of RQCD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RQCD1 recombinant protein

   RQCD1, also known as RCD1, is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. It down-regulates MYB- and JuN-dependent transcription and may play a role in cell differentiation. RQCD1 also plays a role in retinoic acid-controlled lung development. Recombinant human RQCD1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for RQCD1 recombinant protein    Transcription & Translation
 Applications Tested/Suitable for RQCD1 recombinant protein   

SDS-PAGE

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 SDS-Page of RQCD1 recombinant protein    RQCD1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for RQCD1. It may not necessarily be applicable to this product.
 NCBI GI #    4885579
 NCBI GeneID    9125
 NCBI Accession #    NP_005435 [Other Products]
 NCBI GenBank Nucleotide #    NM_005444.2 [Other Products]
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 UniProt Primary Accession #    Q92600 [Other Products]
 UniProt Secondary Accession #    Q96IX4; B2RPI0; B5MDQ4; B7Z1E5 [Other Products]
 UniProt Related Accession #    Q92600 [Other Products]
 Molecular Weight    35.7 kDa (319aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    CCR4-NOT transcription complex subunit 9 isoform 2
 NCBI Official Synonym Full Names    CCR4-NOT transcription complex subunit 9
 NCBI Official Symbol    CNOT9 [Similar Products]
 NCBI Official Synonym Symbols   
RCD1; CAF40; CT129; RCD-1; RQCD1
[Similar Products]
 NCBI Protein Information    CCR4-NOT transcription complex subunit 9; cell differentiation protein RCD1 homolog
 UniProt Protein Name    CCR4-NOT transcription complex subunit 9
 UniProt Synonym Protein Names   
Cell differentiation protein RQCD1 homolog; Rcd-1
 Protein Family    Cell differentiation protein
 UniProt Gene Name    CNOT9 [Similar Products]
 UniProt Synonym Gene Names    Rcd-1 [Similar Products]
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 NCBI Summary for RQCD1    This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]
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 UniProt Comments for RQCD1    Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
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Product References and Citations for RQCD1 recombinant protein

   Garapaty S., et al. (2008) J Biol Chem. 283 (11):6806-16.; Hiroi N., et al. (2002) EMBO J. 21 (19):5235-44.;
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 Research Articles on RQCD1    1. Data indicate a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RQCD1 recombinant proteinPathways associated with RQCD1 recombinant protein
 Reference Product  PubMed Publications
 CNOT1 recombinant protein  >4 publications with RQCD1 and CNOT1
 RQCD1 recombinant protein  >3 publications with RQCD1 and RQCD1
 CNOT2 recombinant protein  >1 publications with RQCD1 and CNOT2
 CNOT3 recombinant protein  >1 publications with RQCD1 and CNOT3
 CNOT7 recombinant protein  >1 publications with RQCD1 and CNOT7
 CNOT6 recombinant protein  >1 publications with RQCD1 and CNOT6
 Products by Pathway  Pathway Diagram
 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
 Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies  Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 TP53 Regulates Transcription Of Cell Cycle Genes Pathway antibodies  TP53 Regulates Transcription Of Cell Cycle Genes Pathway Diagram
Diseases associated with RQCD1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with RQCD1 and Inflammation
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