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RRM2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203601
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RRM2, Recombinant Protein

 Also Known As   

RRM2, 1-389aa, Human, His tag, E Coli

 Product Synonym Names    Ribonucleoside-diphosphate reductase subunit M2; R2; RR2; RR2M; Ribonucleoside-diphosphate reductase subunit M2 Ribonucleotide reductase M2 subunit; Ribonucleotide reductase small subunit
 Product Gene Name   

RRM2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF
 OMIM    X59618 mRNA
 3D Structure    ModBase 3D Structure for P31350
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 Host    E Coli
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 Purity/Purification    > 85% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.1M NaCl
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of RRM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RRM2 recombinant protein

   RRM2, also known as ribonucleotide reductase M2, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. This protein plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. Recombinant human RRM2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques
 Product Categories/Family for RRM2 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for RRM2 recombinant protein   

SDS-PAGE

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 SDS-Page of RRM2 recombinant protein    RRM2 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for RRM2. It may not necessarily be applicable to this product.
 NCBI GI #    4557845
 NCBI GeneID    6241
 NCBI Accession #    NP_001025 [Other Products]
 NCBI GenBank Nucleotide #    NM_001034.3 [Other Products]
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 UniProt Primary Accession #    P31350 [Other Products]
 UniProt Secondary Accession #    Q5WRU7; B2R9B5; J3KP43 [Other Products]
 UniProt Related Accession #    P31350 [Other Products]
 Molecular Weight    47.0 kDa (409aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    ribonucleoside-diphosphate reductase subunit M2 isoform 2
 NCBI Official Synonym Full Names    ribonucleotide reductase regulatory subunit M2
 NCBI Official Symbol    RRM2 [Similar Products]
 NCBI Official Synonym Symbols   
R2; RR2; RR2M
[Similar Products]
 NCBI Protein Information    ribonucleoside-diphosphate reductase subunit M2
 UniProt Protein Name    Ribonucleoside-diphosphate reductase subunit M2
 UniProt Synonym Protein Names   
Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit
 Protein Family    Ribonucleoside-diphosphate reductase
 UniProt Gene Name    RRM2 [Similar Products]
 UniProt Synonym Gene Names    RR2 [Similar Products]
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 NCBI Summary for RRM2    This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
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 UniProt Comments for RRM2    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
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Product References and Citations for RRM2 recombinant protein

   Torrents E, et al. (2002) J Mol Evol. 55 (2):138-52; Herrick J,et al. (2007) Mol Microbiol. 63 (1):22-34;
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 Research Articles on RRM2    1. Data show that inhibition of sphingosine kinase-2 by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2) and c-MYC protein (Myc) in all three cell lines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RRM2 recombinant proteinPathways associated with RRM2 recombinant protein
 Reference Product  PubMed Publications
 RRM1 recombinant protein  >159 publications with RRM2 and RRM1
 CDK1 recombinant protein  >8 publications with RRM2 and CDK1
 PCNA recombinant protein  >4 publications with RRM2 and PCNA
 RFC4 recombinant protein  >2 publications with RRM2 and RFC4
 TYMS recombinant protein  >2 publications with RRM2 and TYMS
 NME1 recombinant protein  >1 publications with RRM2 and NME1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 E2F Mediated Regulation Of DNA Replication Pathway antibodies  E2F Mediated Regulation Of DNA Replication Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 G1/S Transition Pathway antibodies  G1/S Transition Pathway Diagram
 G1/S-Specific Transcription Pathway antibodies  G1/S-Specific Transcription Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Hepatitis C And Hepatocellular Carcinoma Pathway antibodies  Hepatitis C And Hepatocellular Carcinoma Pathway Diagram
Diseases associated with RRM2 recombinant proteinOrgans/Tissues associated with RRM2 recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >41 publications with RRM2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >29 publications with RRM2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >20 publications with RRM2 and Lung Neoplasms
 Lung Diseases Antibodies  >20 publications with RRM2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >15 publications with RRM2 and Neoplasms, Experimental
 Colorectal Neoplasms Antibodies  >15 publications with RRM2 and Colorectal Neoplasms
 Nervous System Diseases Antibodies  >13 publications with RRM2 and Nervous System Diseases
 Liver Diseases Antibodies  >12 publications with RRM2 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >10 publications with RRM2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >8 publications with RRM2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >28 publications with RRM2 and Lung
 Blood Antibodies  >21 publications with RRM2 and Blood
 Liver Antibodies  >15 publications with RRM2 and Liver
 Brain Antibodies  >13 publications with RRM2 and Brain
 Lymph Node Antibodies  >11 publications with RRM2 and Lymph Node
 Lymph Antibodies  >11 publications with RRM2 and Lymph
 Bone Antibodies  >10 publications with RRM2 and Bone
 Nerve Antibodies  >8 publications with RRM2 and Nerve
 Pancreas Antibodies  >8 publications with RRM2 and Pancreas
 Bladder Antibodies  >7 publications with RRM2 and Bladder
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