NP_848660.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
R-spondin-2 isoform 1
NCBI Official Synonym Full Names
R-spondin 2
NCBI Official Synonym Symbols
NCBI Protein Information
R-spondin-2; R-spondin 2 homolog; roof plate-specific spondin-2
UniProt Protein Name
R-spondin-2
UniProt Synonym Protein Names
Roof plate-specific spondin-2
UniProt Synonym Gene Names
UniProt Entry Name
RSPO2_HUMAN
NCBI Summary for RSPO2
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
UniProt Comments for RSPO2
R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Cell development/differentiation; Secreted
Chromosomal Location of Human Ortholog: 8q23.1
Cellular Component: extracellular space; cell surface; extracellular region
Molecular Function: heparin binding; G-protein-coupled receptor binding; receptor binding
Biological Process: embryonic forelimb morphogenesis; osteoblast differentiation; Wnt receptor signaling pathway; embryonic hindlimb morphogenesis; bone mineralization
Research Articles on RSPO2
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Products associated with RSPO2 recombinant protein
Diseases associated with RSPO2 recombinant protein
Organs/Tissues associated with RSPO2 recombinant protein
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