NP_001030307.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,038 Da
NCBI Official Full Name
rab GTPase-activating protein 1-like isoform B
NCBI Official Synonym Full Names
RAB GTPase activating protein 1 like
NCBI Official Synonym Symbols
NCBI Protein Information
rab GTPase-activating protein 1-like
UniProt Protein Name
Rab GTPase-activating protein 1-like
UniProt Comments for RABGAP1L
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration ().
Research Articles on RABGAP1L
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Diseases associated with RABGAP1L recombinant protein
Organs/Tissues associated with RABGAP1L recombinant protein
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