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Rab5a recombinant protein

Scan QR to view Datasheet Catalog #    MBS203135
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rab5a, Recombinant Protein

 Also Known As   

Rab5a, 1-215aa, Human, E Coli

 Product Synonym Names    RAB5A member RAS oncogene family; RAB5A; member RAS oncogene family; RAB5; Rab5a; RAB5A; member RAS oncogene family RAB 5; RAB 5A; RAB5A member RAS oncogene family; RAS associated protein RAB5A; Ras related protein Rab 5A.
 Product Gene Name   

Rab5a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN
 OMIM    M28215 mRNA
 3D Structure    ModBase 3D Structure for P20339
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid in 20mM Tris pH8.0
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of Rab5a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Rab5a recombinant protein

   Rab5a is a member of RAS oncogene family. The small GTPase, Rab5a is a crucial regulatory component of the endocytic pathway. Activation of Rab5a is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex. Recombinant human Rab5a was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for Rab5a recombinant protein    Cancer
 Applications Tested/Suitable for Rab5a recombinant protein   

SDS-PAGE

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 SDS-Page of Rab5a recombinant protein    Rab5a recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for Rab5a. It may not necessarily be applicable to this product.
 NCBI GI #    19923262
 NCBI GeneID    5868
 NCBI Accession #    NP_004153 [Other Products]
 NCBI GenBank Nucleotide #    NM_004162.4 [Other Products]
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 UniProt Primary Accession #    P20339 [Other Products]
 UniProt Secondary Accession #    Q6FI44; B4DJA5 [Other Products]
 UniProt Related Accession #    P20339 [Other Products]
 Molecular Weight    23 kDa (215 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    ras-related protein Rab-5A isoform 1
 NCBI Official Synonym Full Names    RAB5A, member RAS oncogene family
 NCBI Official Symbol    RAB5A [Similar Products]
 NCBI Official Synonym Symbols   
RAB5
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-5A
 UniProt Protein Name    Ras-related protein Rab-5A
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB5A [Similar Products]
 UniProt Synonym Gene Names    RAB5 [Similar Products]
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 UniProt Comments for Rab5a    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 ().
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Product References and Citations for Rab5a recombinant protein

   Tan BK, et al. (2007) J Clin Endocrinol Metab. 92 (7):2590-7 ; Yao-Borengasser A, et al. (2007)) J Clin Endocrinol Metab. 92 (7):2430-2. ;
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 Research Articles on Rab5a    1. Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Rab5a recombinant proteinPathways associated with Rab5a recombinant protein
 Reference Product  PubMed Publications
 EEA1 recombinant protein  >15 publications with Rab5a and EEA1
 PIK3C3 recombinant protein  >2 publications with Rab5a and PIK3C3
 RABGEF1 recombinant protein  >2 publications with Rab5a and RABGEF1
 ZFYVE20 recombinant protein  >1 publications with Rab5a and ZFYVE20
 RABEP1 recombinant protein  >1 publications with Rab5a and RABEP1
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Clathrin-mediated Endocytosis Pathway antibodies  Clathrin-mediated Endocytosis Pathway Diagram
 EGF/EGFR Signaling Pathway antibodies  EGF/EGFR Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
Diseases associated with Rab5a recombinant proteinOrgans/Tissues associated with Rab5a recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with Rab5a and Inflammation
 Liver Diseases Antibodies  >6 publications with Rab5a and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with Rab5a and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with Rab5a and Liver Neoplasms
 Kidney Diseases Antibodies  >4 publications with Rab5a and Kidney Diseases
 Brain Diseases Antibodies  >3 publications with Rab5a and Brain Diseases
 Fibrosis Antibodies  >2 publications with Rab5a and Fibrosis
 Uterine Cervical Neoplasms Antibodies  >2 publications with Rab5a and Uterine Cervical Neoplasms
 Weight Loss Antibodies  >2 publications with Rab5a and Weight Loss
 Necrosis Antibodies  >2 publications with Rab5a and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with Rab5a and Brain
 Kidney Antibodies  >17 publications with Rab5a and Kidney
 Blood Antibodies  >16 publications with Rab5a and Blood
 Lung Antibodies  >15 publications with Rab5a and Lung
 Liver Antibodies  >11 publications with Rab5a and Liver
 Vascular Antibodies  >11 publications with Rab5a and Vascular
 Nerve Antibodies  >9 publications with Rab5a and Nerve
 Muscle Antibodies  >8 publications with Rab5a and Muscle
 Heart Antibodies  >8 publications with Rab5a and Heart
 Skin Antibodies  >5 publications with Rab5a and Skin
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