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RAC1 recombinant protein :: Ras-Related C3 Botulinum Toxin substrate 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143542 RAC1 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ras-Related C3 Botulinum Toxin substrate 1 (RAC1), Recombinant Protein

 Also Known As   

Recombinant Human Ras-Related C3 Botulinum Toxin substrate 1 His Tag

 Product Synonym Names    RAC1 Human, His; Ras-Related C3 Botulinum Toxin substrate 1 Human Recombinant, His Tag; P21-RAC1; RAC-1; RAC1; RAS-like protein TC25; MIG5; Cell-migration-inducing gene 5 protein; Ras-related C3 botulinum toxin substrate 1; rho family small GTP binding protein Rac1; TC-25; MGC111543; RAC1 His
 Product Gene Name   

RAC1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL
 OMIM    602048
 3D Structure    ModBase 3D Structure for P63000
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The RAC1 His Tag protein solution contains 20mM Tris-HCl pH7.5, 1mM EDTA, 10% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of RAC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RAC1 recombinant protein

   Description: Ras-Related C3 Botulinum Toxin substrate 1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-192 a.a.) and having a molecular mass of 23.6 kDa. RAC1 contains a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.

Introduction: RAC1 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. RAC-1 regulates the actin cytoskeleton but also other cellular processes. RAC1 have been shown to be involved in the regulation of cell-cell adhesion.
 Product Categories/Family for RAC1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Ras-Related C3 Botulinum Toxin Substrate
NCBI/Uniprot data below describe general gene information for RAC1. It may not necessarily be applicable to this product.
 NCBI GI #    9845511
 NCBI GeneID    5879
 NCBI Accession #    NP_008839.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006908.4 [Other Products]
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 UniProt Primary Accession #    P63000 [Other Products]
 UniProt Secondary Accession #    O95501; P15154; Q3Y4D3; Q5JAA8; Q9BTB4 [Other Products]
 UniProt Related Accession #    P63000; AAB22206 [Other Products]
 Molecular Weight    23,467 Da
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 NCBI Official Full Name    ras-related C3 botulinum toxin substrate 1 isoform Rac1
 NCBI Official Synonym Full Names    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
 NCBI Official Symbol    RAC1 [Similar Products]
 NCBI Official Synonym Symbols   
MIG5; Rac-1; TC-25; p21-Rac1
[Similar Products]
 NCBI Protein Information    ras-related C3 botulinum toxin substrate 1; cell migration-inducing gene 5 protein; ras-like protein TC25
 UniProt Protein Name    Ras-related C3 botulinum toxin substrate 1
 UniProt Synonym Protein Names   
Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1
 Protein Family    Ras-related protein
 UniProt Gene Name    RAC1 [Similar Products]
 UniProt Synonym Gene Names    TC25 [Similar Products]
 UniProt Entry Name    RAC1_HUMAN
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 NCBI Summary for RAC1    The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for RAC1    RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described.

Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: Golgi membrane; extrinsic to plasma membrane; focal adhesion; membrane; lamellipodium; cytoplasm; plasma membrane; melanosome; actin filament; trans-Golgi network; cytosol; phagocytic cup

Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; GTP-dependent protein binding; Rho GDP-dissociation inhibitor binding; thioesterase binding; protein kinase binding; Rab GTPase binding

Biological Process: nerve growth factor receptor signaling pathway; viral reproduction; metabolic process; positive regulation of apoptosis; cell motility involved in cell locomotion; regulation of cell migration; small GTPase mediated signal transduction; positive regulation of stress fiber formation; cell adhesion; bone resorption; platelet activation; anatomical structure morphogenesis; mast cell chemotaxis; dendrite morphogenesis; positive regulation of Rho protein signal transduction; regulation of defense response to virus by virus; negative regulation of interleukin-23 production; T cell costimulation; cerebral cortex radially oriented cell migration; actin cytoskeleton organization and biogenesis; axon guidance; cell-matrix adhesion; localization within membrane; positive regulation of focal adhesion formation; actin filament polymerization; ephrin receptor signaling pathway; response to wounding; inflammatory response; regulation of hydrogen peroxide metabolic process; lamellipodium biogenesis; embryonic olfactory bulb interneuron precursor migration; intercellular junction assembly and maintenance; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of phosphoinositide 3-kinase activity; engulfment of apoptotic cell; cell proliferation; G-protein coupled receptor protein signaling pathway; hyperosmotic response; positive regulation of actin filament polymerization; organization of an anatomical structure; auditory receptor cell morphogenesis; ruffle organization and biogenesis; innate immune response; negative regulation of receptor-mediated endocytosis; positive regulation of protein amino acid phosphorylation; cell motility; blood coagulation; vascular endothelial growth factor receptor signaling pathway; positive regulation of DNA replication
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 Research Articles on RAC1    1. data show that bile acids are key in the breakdown of the blood-brain barrier during cholestatic liver disease, and that these permeabilizing effects were due to the activation of Rac1 and downstream phosphorylation of the tight junction protein occludin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RAC1 recombinant proteinPathways associated with RAC1 recombinant protein
 Reference Product  PubMed Publications
 PAK1 recombinant protein  >283 publications with RAC1 and PAK1
 TIAM1 recombinant protein  >180 publications with RAC1 and TIAM1
 VAV1 recombinant protein  >104 publications with RAC1 and VAV1
 IQGAP1 recombinant protein  >101 publications with RAC1 and IQGAP1
 AKT1 recombinant protein  >62 publications with RAC1 and AKT1
 PAK2 recombinant protein  >44 publications with RAC1 and PAK2
 DOCK1 recombinant protein  >43 publications with RAC1 and DOCK1
 ARHGDIA recombinant protein  >32 publications with RAC1 and ARHGDIA
 ARFIP2 recombinant protein  >8 publications with RAC1 and ARFIP2
 NCF2 recombinant protein  >3 publications with RAC1 and NCF2
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with RAC1 recombinant proteinOrgans/Tissues associated with RAC1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >280 publications with RAC1 and Inflammation
 Neoplasm Metastasis Antibodies  >228 publications with RAC1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >214 publications with RAC1 and Disease Models, Animal
 Necrosis Antibodies  >168 publications with RAC1 and Necrosis
 Brain Diseases Antibodies  >164 publications with RAC1 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >154 publications with RAC1 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >132 publications with RAC1 and Heart Diseases
 Hypertension Antibodies  >124 publications with RAC1 and Hypertension
 Fibrosis Antibodies  >107 publications with RAC1 and Fibrosis
 Atherosclerosis Antibodies  >101 publications with RAC1 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >907 publications with RAC1 and Blood
 Vascular Antibodies  >737 publications with RAC1 and Vascular
 Brain Antibodies  >555 publications with RAC1 and Brain
 Muscle Antibodies  >499 publications with RAC1 and Muscle
 Lung Antibodies  >335 publications with RAC1 and Lung
 Nerve Antibodies  >319 publications with RAC1 and Nerve
 Kidney Antibodies  >292 publications with RAC1 and Kidney
 Heart Antibodies  >281 publications with RAC1 and Heart
 Bone Antibodies  >227 publications with RAC1 and Bone
 Embryonic Tissue Antibodies  >173 publications with RAC1 and Embryonic Tissue
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